Sadler House may refer to:

in the United States (by state then city)

• Sadler House (McCalla, Alabama), listed on the National Register of Historic Places (NRHP) in Jefferson County]]
• Terrell-Sadler House, Harmony, Georgia, listed on the NRHP in Putnam County
• Herbert A. Sadler House, Attleboro, Massachusetts, listed on the NRHP in Bristol County
• Sadler House (Aberdeen, Mississippi), listed on the NRHP in Monroe County
• Gov. Reinhold Sadler House, Carson City, Nevada, listed on the NRHP in Carson City
• Sadler House (Montclair, New Jersey), listed on the NRHP in Essex County, New Jersey
• Samuel Sadler House, Sandy Creek, New York, listed on the NRHP in Oswego County

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