释义 |
- Interactions
- References
- Further reading
- External links
{{Infobox_gene}}SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.[1][2][3][4] Interactions SAE1 has been shown to interact with SAE2.[1][3][5][6] References 1. ^1 {{cite journal | vauthors = Desterro JM, Rodriguez MS, Kemp GD, Hay RT | title = Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1 | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 10618–24 | date = May 1999 | pmid = 10187858 | pmc = | doi = 10.1074/jbc.274.15.10618 }} 2. ^{{cite journal | vauthors = Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H | title = In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2 | journal = Biochem. Biophys. Res. Commun. | volume = 254 | issue = 3 | pages = 693–8 | date = Mar 1999 | pmid = 9920803 | pmc = | doi = 10.1006/bbrc.1998.9995 }} 3. ^1 {{cite journal | vauthors = Gong L, Li B, Millas S, Yeh ET | title = Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex | journal = FEBS Lett. | volume = 448 | issue = 1 | pages = 185–9 | date = Jun 1999 | pmid = 10217437 | pmc = | doi = 10.1016/S0014-5793(99)00367-1 }} 4. ^{{cite web | title = Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10055| accessdate = }} 5. ^{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }} 6. ^{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Res. | volume = 10 | issue = 10 | pages = 1546–60 | year = 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
- {{cite journal | vauthors = Tatham MH, Jaffray E, Vaughan OA, Desterro JM, Botting CH, Naismith JH, Hay RT | title = Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9 | journal = J. Biol. Chem. | volume = 276 | issue = 38 | pages = 35368–74 | year = 2001 | pmid = 11451954 | doi = 10.1074/jbc.M104214200 }}
- {{cite journal | vauthors = Azuma Y, Tan SH, Cavenagh MM, Ainsztein AM, Saitoh H, Dasso M | title = Expression and regulation of the mammalian SUMO-1 E1 enzyme | journal = FASEB J. | volume = 15 | issue = 10 | pages = 1825–7 | year = 2001 | pmid = 11481243 | doi = 10.1096/fj.00-0818fje }}
- {{cite journal | vauthors = Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y | title = Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation | journal = Biochemistry | volume = 42 | issue = 33 | pages = 9959–69 | year = 2003 | pmid = 12924945 | doi = 10.1021/bi0345283 }}
- {{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S | title = Complete sequencing and characterization of 21,243 full-length human cDNAs | journal = Nat. Genet. | volume = 36 | issue = 1 | pages = 40–5 | year = 2004 | pmid = 14702039 | doi = 10.1038/ng1285 }}
- {{cite journal | vauthors = Komatsu T, Mizusaki H, Mukai T, Ogawa H, Baba D, Shirakawa M, Hatakeyama S, Nakayama KI, Yamamoto H, Kikuchi A, Morohashi K | title = Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9 | journal = Mol. Endocrinol. | volume = 18 | issue = 10 | pages = 2451–62 | year = 2004 | pmid = 15192080 | doi = 10.1210/me.2004-0173 }}
- {{cite journal | vauthors = Salinas S, Briançon-Marjollet A, Bossis G, Lopez MA, Piechaczyk M, Jariel-Encontre I, Debant A, Hipskind RA | title = SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1 | journal = J. Cell Biol. | volume = 165 | issue = 6 | pages = 767–73 | year = 2004 | pmid = 15210726 | pmc = 2172397 | doi = 10.1083/jcb.200310136 }}
- {{cite journal | vauthors = Lin JY, Ohshima T, Shimotohno K | title = Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53 | journal = FEBS Lett. | volume = 573 | issue = 1-3 | pages = 15–8 | year = 2004 | pmid = 15327968 | doi = 10.1016/j.febslet.2004.07.059 }}
- {{cite journal | vauthors = Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S | title = A mechanism for inhibiting the SUMO pathway | journal = Mol. Cell | volume = 16 | issue = 4 | pages = 549–61 | year = 2004 | pmid = 15546615 | doi = 10.1016/j.molcel.2004.11.007 }}
- {{cite journal | vauthors = Lois LM, Lima CD | title = Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1 | journal = EMBO J. | volume = 24 | issue = 3 | pages = 439–51 | year = 2005 | pmid = 15660128 | pmc = 548657 | doi = 10.1038/sj.emboj.7600552 }}
- {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
- {{cite journal | vauthors = Klenk C, Humrich J, Quitterer U, Lohse MJ | title = SUMO-1 controls the protein stability and the biological function of phosducin | journal = J. Biol. Chem. | volume = 281 | issue = 13 | pages = 8357–64 | year = 2006 | pmid = 16421094 | doi = 10.1074/jbc.M513703200 }}
- {{cite journal | vauthors = Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB | title = A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers | journal = Arch. Biochem. Biophys. | volume = 453 | issue = 1 | pages = 70–4 | year = 2006 | pmid = 16620772 | doi = 10.1016/j.abb.2006.03.002 }}
- {{cite journal | vauthors = Pan X, Li H, Zhang P, Jin B, Man J, Tian L, Su G, Zhao J, Li W, Liu H, Gong W, Zhou T, Zhang X | title = Ubc9 interacts with SOX4 and represses its transcriptional activity | journal = Biochem. Biophys. Res. Commun. | volume = 344 | issue = 3 | pages = 727–34 | year = 2006 | pmid = 16631117 | doi = 10.1016/j.bbrc.2006.03.194 }}
{{refend}} External links - {{UCSC genome browser|SAE1}}
- {{UCSC gene details|SAE1}}
{{PDB Gallery|geneid=10055}}{{gene-19-stub}} |