| 词条 | Saos-2 cells |
| 释义 |
In 1987 Rodan et al. determined that Saos-2 cells "possess several osteoblastic features and could be useful as a permanent line of human osteoblast-like cells and as a source of bone-related molecules."[3] Besides their worldwide availability, some of the advantages for using Saos-2 cell line are that they have well-documented characterization data, the possibility to obtain large amounts of cells in short time, and the fact that Saos-2 cells can be fully differentiated in a manner that the osteoblastic cells naturally do.[4] The latter point is described particularly as "the ability of Saos-2 cells to deposit a mineralization-competent extracellular matrix",[5] which makes these cells a valuable model for studying events associated with the late osteoblastic differentiation stage in human cells.[6] References1. ^{{cite journal |vauthors=Fogh J, Fogh JM, Orfeo T | year = 1977 | title = One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice | journal = J Natl Cancer Inst | volume = 59 | issue = 1 | pages = 221–226 | PMID= 327080 | doi = 10.1093/jnci/59.1.221 |url=https://academic.oup.com/jnci/article-abstract/59/1/221/888247?redirectedFrom=PDF}} 2. ^{{cite web|publisher=ATCC|url=https://www.atcc.org/Products/All/HTB-85.aspx|title=Saos-2|access-date=11 June 2018}} 3. ^{{ cite journal |vauthors=Rodan SB, Imai Y, Thiede MA, Wesolowski G, Thompson D, Bar-Shavit Z, Shull S, Mann K, Rodan GA | year = 1987 | title = Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties |pmid=3040234| journal = Cancer Res. | volume = 47 | issue = 18 | pages = 4961–6}} 4. ^{{cite journal |vauthors=Hausser HJ, Brenner RE |pmid=15939397| title = Phenotypic instability of Saos-2 cells in long-term culture | journal = Biochem. Biophys. Res. Commun. | year = 2005 | volume = 333 | issue = 1 | pages = 216–22| doi=10.1016/j.bbrc.2005.05.097}} 5. ^{{cite journal |vauthors=McQuillan DJ, Richardson MD, Bateman JF | title = Matrix deposition by a calcifying human osteogenic sarcoma cell line (SAOS- 2) |pmid=7605701|doi=10.1016/8756-3282(95)90186-8 | journal = Bone | year = 1995 | volume = 16 | issue = 4 | pages = 415–26}} 6. ^{{cite journal |vauthors=Gundle R, Beresford JN | year = 1995 | title = The isolation and culture of cells from explants of human trabecular bone | journal = Calcif. Tissue Int. | volume = 56 | issue = Suppl 1 | page = S8-10 | PMID= 7719993|doi=10.1007/BF03354640}} External links
1 : Human cell lines |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。