| 词条 | SAP18 |
| 释义 |
FunctionHistone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.[2] Additionally, SAP18s splice variants are implicated in apoptotic cycles.[3] InteractionsSAP18 has been shown to interact with
References1. ^{{cite journal | vauthors = Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D | title = Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex | journal = Cell | volume = 89 | issue = 3 | pages = 357–64 | date = May 1997 | pmid = 9150135 | pmc = | doi = 10.1016/S0092-8674(00)80216-0 }} 2. ^1 {{cite web | title = Entrez Gene: SAP18 Sin3A-associated protein, 18kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10284| accessdate = }} 3. ^{{cite journal | vauthors = Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, Garneau D, Gendron D, Lapointe E, Couture S, Le Hir H, Klinck R, Elela SA, Prinos P, Chabot B | title = Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators | journal = Molecular and Cellular Biology | volume = 32 | issue = 5 | pages = 954–67 | date = March 2012 | pmid = 22203037 | pmc = 3295189 | doi = 10.1128/MCB.06130-11 }} 4. ^{{cite journal | vauthors = Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F | title = The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA | journal = Journal of Biochemistry | volume = 131 | issue = 3 | pages = 307–11 | date = March 2002 | pmid = 11872158 | doi = 10.1093/oxfordjournals.jbchem.a003104 }} 5. ^{{cite journal | vauthors = Cheng SY, Bishop JM | title = Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 8 | pages = 5442–7 | date = April 2002 | pmid = 11960000 | pmc = 122788 | doi = 10.1073/pnas.082096999 }} 6. ^{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }} Further reading{{refbegin | 2}}
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