| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.[1][1][2][2][3]The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.[3] Interactions SART3 has been shown to interact with RNPS1[4] and Androgen receptor.[5] References 1. ^1 {{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = August 1995 | pmid = 8590280 | pmc = | doi = 10.1093/dnares/2.4.167 }}
2. ^1 {{cite journal | vauthors = Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K | title = Mouse homologue of the human SART3 gene encoding tumor-rejection antigen | journal = Japanese Journal of Cancer Research | volume = 91 | issue = 2 | pages = 239–47 | date = February 2000 | pmid = 10761712 | pmc = 5926322| doi = 10.1111/j.1349-7006.2000.tb00937.x }}
3. ^1 {{cite web | title = Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9733| accessdate = }}
4. ^{{cite journal | vauthors = Harada K, Yamada A, Yang D, Itoh K, Shichijo S | title = Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation | journal = International Journal of Cancer | volume = 93 | issue = 5 | pages = 623–8 | date = September 2001 | pmid = 11477570 | doi = 10.1002/ijc.1391 }}
5. ^{{cite journal | vauthors = Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ | title = Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 21766–73 | date = May 2004 | pmid = 15031286 | doi = 10.1074/jbc.M314321200 }}
Further reading {{Refbegin | 2}}- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Yang D, Nakao M, Shichijo S, Sasatomi T, Takasu H, Matsumoto H, Mori K, Hayashi A, Yamana H, Shirouzu K, Itoh K | title = Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients | journal = Cancer Research | volume = 59 | issue = 16 | pages = 4056–63 | date = August 1999 | pmid = 10463607 | doi = }}
- {{cite journal | vauthors = Tanaka S, Tsuda N, Kawano K, Sakamoto M, Nishida T, Hashimoto T, Shichijo S, Kamura T, Itoh K | title = Expression of tumor-rejection antigens in gynecologic cancers | journal = Japanese Journal of Cancer Research | volume = 91 | issue = 11 | pages = 1177–84 | date = November 2000 | pmid = 11092984 | pmc = 5926290 | doi = 10.1111/j.1349-7006.2000.tb00902.x }}
- {{cite journal | vauthors = Harada K, Yamada A, Yang D, Itoh K, Shichijo S | title = Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation | journal = International Journal of Cancer | volume = 93 | issue = 5 | pages = 623–8 | date = September 2001 | pmid = 11477570 | doi = 10.1002/ijc.1391 }}
- {{cite journal | vauthors = Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K | title = Expression of tumor rejection antigens in colorectal carcinomas | journal = Cancer | volume = 94 | issue = 6 | pages = 1636–41 | date = March 2002 | pmid = 11920522 | doi = 10.1002/cncr.10421 }}
- {{cite journal | vauthors = Liu Y, Li J, Kim BO, Pace BS, He JJ | title = HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23854–63 | date = June 2002 | pmid = 11959860 | doi = 10.1074/jbc.M200773200 }}
- {{cite journal | vauthors = Bell M, Schreiner S, Damianov A, Reddy R, Bindereif A | title = p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor | journal = The EMBO Journal | volume = 21 | issue = 11 | pages = 2724–35 | date = June 2002 | pmid = 12032085 | pmc = 126028 | doi = 10.1093/emboj/21.11.2724 }}
- {{cite journal | vauthors = Nottrott S, Urlaub H, Lührmann R | title = Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins | journal = The EMBO Journal | volume = 21 | issue = 20 | pages = 5527–38 | date = October 2002 | pmid = 12374753 | pmc = 129076 | doi = 10.1093/emboj/cdf544 }}
- {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = November 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
- {{cite journal | vauthors = Stanĕk D, Rader SD, Klingauf M, Neugebauer KM | title = Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies | journal = The Journal of Cell Biology | volume = 160 | issue = 4 | pages = 505–16 | date = February 2003 | pmid = 12578909 | pmc = 2173746 | doi = 10.1083/jcb.200210087 }}
- {{cite journal | vauthors = Damianov A, Schreiner S, Bindereif A | title = Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP | journal = Molecular and Cellular Biology | volume = 24 | issue = 4 | pages = 1700–8 | date = February 2004 | pmid = 14749385 | pmc = 344176 | doi = 10.1128/MCB.24.4.1700-1708.2004 }}
- {{cite journal | vauthors = Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ | title = Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 21766–73 | date = May 2004 | pmid = 15031286 | doi = 10.1074/jbc.M314321200 }}
- {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
- {{cite journal | vauthors = Medenbach J, Schreiner S, Liu S, Lührmann R, Bindereif A | title = Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling | journal = Molecular and Cellular Biology | volume = 24 | issue = 17 | pages = 7392–401 | date = September 2004 | pmid = 15314151 | pmc = 506986 | doi = 10.1128/MCB.24.17.7392-7401.2004 }}
- {{cite journal | vauthors = Stanĕk D, Neugebauer KM | title = Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer | journal = The Journal of Cell Biology | volume = 166 | issue = 7 | pages = 1015–25 | date = September 2004 | pmid = 15452143 | pmc = 2172029 | doi = 10.1083/jcb.200405160 }}
{{Refend}}{{PDB Gallery|geneid=9733}}{{Gene-12-stub}} 1 : Spliceosome |