S.C. 22 may refer to:

• South Carolina Highway 22
• {{USS|SC-22}}, a United States Navy submarine chaser in commission from 1917 to 1919

• 1279 in poetry
• 127 Avenue, Edmonton
• 127 (band)
• 127(band)
• 127BC
• 12.7 cm/40 Type 89 naval gun
• 12.7 cm/50 Type 3 naval gun
• 127 Hours
• 127 hours
• 127 Hours (soundtrack)
• 12.7 mm round
• 127 Rose Avenue
• 127 series
• 127 SQN
• 127 Squadron, Republic of Singapore Air Force
• 127th
• 127th (12th York Rangers) Battalion, CEF
• 127th Baluchis
• 127th Baluch Light Infantry
• 127th Bomb Squadron
• 127th Command and Control Squadron
• 127th Delaware General Assembly
• 127th (disambiguation)
• 127th Fighter Squadron
• 127th Illinois Infantry Regiment