| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 is a protein that in humans is encoded by the AIMP1 gene.[1][2][3]The protein encoded by this gene is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multiaminoacyl-tRNA synthetase complex (mARS). Pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.[3] As an inflammatory cytokine, AIMp1/p43 has demonstrated the ability to skew T-helper polarization in the direction of Th-1, and its homozygous deletion leads to a hyper-polarized Th-2 phenotype. InteractionsSCYE1 has been shown to interact with SMURF2.[4] References1. ^{{cite journal |vauthors=Kao J, Houck K, Fan Y, Haehnel I, Libutti SK, Kayton ML, Grikscheit T, Chabot J, Nowygrod R, Greenberg S, etal | title = Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II | journal = J Biol Chem | volume = 269 | issue = 40 | pages = 25106–19 |date=Nov 1994 | pmid = 7929199 | pmc = | doi = }}
2. ^{{cite journal |vauthors=Kao J, Fan YG, Haehnel I, Brett J, Greenberg S, Clauss M, Kayton M, Houck K, Kisiel W, Seljelid R, etal | title = A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response | journal = J Biol Chem | volume = 269 | issue = 13 | pages = 9774–82 |date=May 1994 | pmid = 7545917 | pmc = | doi = }}
3. ^1 {{cite web | title = Entrez Gene: SCYE1 small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9255| accessdate = }}
4. ^{{cite journal |last=Lee |first=Yeon Sook |authorlink= |author2=Han Jung Min |author3=Son Sung Hwa |author4=Choi Jin Woo |author5=Jeon Eun Ju |author6=Bae Suk-Chul |author7=Park Young In |author8=Kim Sunghoon |date=Jul 2008 |title=AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2 |journal=Biochem. Biophys. Res. Commun. |volume=371 |issue=3 |pages=395–400 |publisher= |location = United States| issn = | pmid = 18448069 |doi = 10.1016/j.bbrc.2008.04.099 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Kao J, Ryan J, Brett G, etal |title=Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms |journal=J. Biol. Chem. |volume=267 |issue= 28 |pages= 20239–47 |year= 1992 |pmid= 1400342 |doi= }}
- {{cite journal |author1=Quevillon S |author2=Agou F |author3=Robinson JC |author4=Mirande M |title=The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32573–9 |year= 1998 |pmid= 9405472 |doi=10.1074/jbc.272.51.32573 }}
- {{cite journal |vauthors=Quevillon S, Robinson JC, Berthonneau E, etal |title=Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein |journal=J. Mol. Biol. |volume=285 |issue= 1 |pages= 183–95 |year= 1999 |pmid= 9878398 |doi= 10.1006/jmbi.1998.2316 }}
- {{cite journal |vauthors=Park SG, Jung KH, Lee JS, etal |title=Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16673–6 |year= 1999 |pmid= 10358004 |doi=10.1074/jbc.274.24.16673 }}
- {{cite journal |vauthors=Kim Y, Shin J, Li R, etal |title=A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27062–8 |year= 2000 |pmid= 10852899 |doi= 10.1074/jbc.C000216200 }}
- {{cite journal |vauthors=Renault L, Kerjan P, Pasqualato S, etal |title=Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry |journal=EMBO J. |volume=20 |issue= 3 |pages= 570–8 |year= 2001 |pmid= 11157763 |doi= 10.1093/emboj/20.3.570 | pmc=133484 }}
- {{cite journal |vauthors=Shalak V, Kaminska M, Mitnacht-Kraus R, etal |title=The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23769–76 |year= 2001 |pmid= 11306575 |doi= 10.1074/jbc.M100489200 }}
- {{cite journal |author1=Chang SY |author2=Park SG |author3=Kim S |author4=Kang CY |title=Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8388–94 |year= 2002 |pmid= 11741979 |doi= 10.1074/jbc.M108792200 }}
- {{cite journal |author1=Battersby S |author2=Boddy SC |author3=Critchley HO |author4=Jabbour HN |title=Expression and localization of endothelial monocyte-activating polypeptide II in the human endometrium across the menstrual cycle: regulation of expression by prostaglandin E(2) |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 8 |pages= 3928–35 |year= 2002 |pmid= 12161535 |doi=10.1210/jc.87.8.3928 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Park H, Park SG, Kim J, etal |title=Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43 |journal=Cytokine |volume=20 |issue= 4 |pages= 148–53 |year= 2003 |pmid= 12543078 |doi=10.1006/cyto.2002.1992 }}
- {{cite journal |author1=Ahn HC |author2=Kim S |author3=Lee BJ |title=Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43 |journal=FEBS Lett. |volume=542 |issue= 1–3 |pages= 119–24 |year= 2003 |pmid= 12729910 |doi=10.1016/S0014-5793(03)00362-4 }}
- {{cite journal |vauthors=Kim MJ, Park BJ, Kang YS, etal |title=Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation |journal=Nat. Genet. |volume=34 |issue= 3 |pages= 330–6 |year= 2003 |pmid= 12819782 |doi= 10.1038/ng1182 }}
- {{cite journal |vauthors=Wolfe CL, Warrington JA, Davis S, etal |title=Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII |journal=Protein Sci. |volume=12 |issue= 10 |pages= 2282–90 |year= 2004 |pmid= 14500886 |doi=10.1110/ps.03147903 | pmc=2366922 }}
- {{cite journal |vauthors=Mueller CA, Schluesener HJ, Conrad S, etal |title=Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II |journal=J. Neurotrauma |volume=20 |issue= 10 |pages= 1007–15 |year= 2004 |pmid= 14588117 |doi= 10.1089/089771503770195858 }}
- {{cite journal |vauthors=Murray JC, Symonds P, Ward W, etal |title=Colorectal cancer cells induce lymphocyte apoptosis by an endothelial monocyte-activating polypeptide-II-dependent mechanism |journal=J. Immunol. |volume=172 |issue= 1 |pages= 274–81 |year= 2004 |pmid= 14688335 |doi= 10.4049/jimmunol.172.1.274}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Murray JC, Heng YM, Symonds P, etal |title=Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis |journal=J. Leukoc. Biol. |volume=75 |issue= 5 |pages= 772–6 |year= 2004 |pmid= 14982944 |doi= 10.1189/jlb.1003487 }}
{{refend}}{{PDB Gallery|geneid=9255}}{{gene-4-stub}} |