SD-1 may refer to:

• South Dakota's 1st congressional district, a United States electoral district
• Spacek SD-1 Minisport, a Czech amateur-built aircraft design
• MSD SD-1, a floppy disk drive station for Commodore computers
• Northrop SD-1 drone, a battlefield reconnaissance drone of the 1960s

• Minister of State for Petroleum and Natural Gas (India)
• Minister of State for Policing
• Minister of State for Primary Care, Mental Health and Disability
• Minister of State for Relations with Parliament (Albania)
• Minister of State for Social Security
• Minister of State (France)
• Minister of State (India)
• Minister of State of Artsakh
• Minister of State of Georgia
• Minister of State of Innovation and Public Administration (Albania)
• Minister of State of Women and Children Affairs
• Minister of State Owned Enterprises
• Minister of State (Republic of China)
• Minister of State Services
• Minister of State (Sport)
• Minister of State (Turkey)
• Minister of State (United Kingdom)
• Minister of Technology and Research (Sri Lanka)
• Minister of Telecommunication and Digital Infrastructure (Sri Lanka)
• Minister of Telecommunications and Information Society (Serbia)
• Minister of Telecommunications and Postal Services (South Africa)
• Minister of Territorial Policy and Public Works (Catalonia)
• Minister of Territories (Malaysia)
• Minister of Territory Administration and State Reform (Angola)
• Minister of Territory and Sustainability (Catalonia)