| 词条 | SDZ SER-082 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 449587176 | IUPAC_name = (+)-cis 4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine | image = SDZ SER-082.svg | width = 170 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 141474-54-6 | PubChem = 9859407 | IUPHAR_ligand = 195 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 8035107 | C=15 | H=20 | N=2 | molecular_weight = 228.332 g/mol | smiles = CN1CC[C@@H]2CN3CCC4=C3C(=CC=C4)[C@@H]2C1 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C15H20N2/c1-16-7-5-12-9-17-8-6-11-3-2-4-13(15(11)17)14(12)10-16/h2-4,12,14H,5-10H2,1H3/t12-,14-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = YASBOGFWAMXINH-TZMCWYRMSA-N }}SDZ SER-082 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.[1] It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes,[2][3][4] and how they influence the effects of other drugs such as cocaine.[5][6][7] References1. ^Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. Journal of Medicinal Chemistry. 1995 Jan;38(1):28-33. {{doi|10.1021/jm00001a007}} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Mora PO, Netto CF, Graeff FG |title=Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze |journal=Pharmacology Biochemistry and Behavior |volume=58 |issue=4 |pages=1051–7 |date=December 1997 |pmid=9408213 |doi= 10.1016/S0091-3057(97)00057-9|url=}} 3. ^{{cite journal |vauthors=Dave KD, Harvey JA, Aloyo VJ |title=A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation |journal=Pharmacology Biochemistry and Behavior |volume=72 |issue=1-2 |pages=371–8 |date=May 2002 |pmid=11900808 |doi= 10.1016/S0091-3057(01)00767-5|url=}} 4. ^{{cite journal |vauthors=Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA |title=Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat |journal=Pharmacology Biochemistry and Behavior |volume=90 |issue=4 |pages=632–9 |date=October 2008 |pmid=18572227 |doi=10.1016/j.pbb.2008.05.006 |url=}} 5. ^{{cite journal |vauthors=Filip M, Bubar MJ, Cunningham KA |title=Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=310 |issue=3 |pages=1246–54 |date=September 2004 |pmid=15131246 |doi=10.1124/jpet.104.068841 |url=}} 6. ^{{cite journal |author=Filip M |title=Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats |journal=Pharmacological Reports : PR |volume=57 |issue=1 |pages=35–46 |year=2005 |pmid=15849375 |doi= |url=}} 7. ^{{cite journal |vauthors=Filip M, Bubar MJ, Cunningham KA |title=Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats |journal=Psychopharmacology |volume=183 |issue=4 |pages=482–9 |date=January 2006 |pmid=16261316 |doi=10.1007/s00213-005-0197-y |url=}} 2 : 5-HT2 antagonists|Indolonaphthyridines |
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