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词条 SEC14L2
释义

  1. Function

  2. References

  3. Further reading

{{Infobox_gene}}SEC14-like protein 2 is a protein that in humans is encoded by the SEC14L2 gene.[1][2]

Function

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway.[2]

References

1. ^{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | pmc = | doi = 10.1038/990031 }}
2. ^1 {{cite web | title = Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23541| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Caras IW, Friedlander EJ, Bloch K | title = Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids | journal = J. Biol. Chem. | volume = 255 | issue = 8 | pages = 3575–80 | year = 1980 | pmid = 7364757 | doi = }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Solheim JC, Harris MR, Kindle CS, Hansen TH | title = Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing | journal = J. Immunol. | volume = 158 | issue = 5 | pages = 2236–41 | year = 1997 | pmid = 9036970 | doi = }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1999 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
  • {{cite journal | vauthors = Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O | title = Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain | journal = DNA Res. | volume = 6 | issue = 5 | pages = 329–36 | year = 2000 | pmid = 10574461 | doi = 10.1093/dnares/6.5.329 }}
  • {{cite journal | vauthors = Zimmer S, Stocker A, Sarbolouki MN, Spycher SE, Sassoon J, Azzi A | title = A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25672–80 | year = 2000 | pmid = 10829015 | doi = 10.1074/jbc.M000851200 }}
  • {{cite journal | vauthors = Shibata N, Arita M, Misaki Y, Dohmae N, Takio K, Ono T, Inoue K, Arai H | title = Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 5 | pages = 2244–9 | year = 2001 | pmid = 11226224 | pmc = 30123 | doi = 10.1073/pnas.041620398 }}
  • {{cite journal | vauthors = Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O | title = Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping | journal = DNA Res. | volume = 8 | issue = 1 | pages = 1–9 | year = 2001 | pmid = 11258795 | doi = 10.1093/dnares/8.1.1 }}
  • {{cite journal | vauthors = Yamauchi J, Iwamoto T, Kida S, Masushige S, Yamada K, Esashi T | title = Tocopherol-associated protein is a ligand-dependent transcriptional activator | journal = Biochem. Biophys. Res. Commun. | volume = 285 | issue = 2 | pages = 295–9 | year = 2001 | pmid = 11444841 | doi = 10.1006/bbrc.2001.5162 }}
  • {{cite journal | vauthors = Stocker A, Tomizaki T, Schulze-Briese C, Baumann U | title = Crystal structure of the human supernatant protein factor | journal = Structure | volume = 10 | issue = 11 | pages = 1533–40 | year = 2003 | pmid = 12429094 | doi = 10.1016/S0969-2126(02)00884-5 }}
  • {{cite journal | vauthors = Singh DK, Mokashi V, Elmore CL, Porter TD | title = Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 5646–51 | year = 2003 | pmid = 12454003 | doi = 10.1074/jbc.M211750200 }}
  • {{cite journal | vauthors = Kempná P, Zingg JM, Ricciarelli R, Hierl M, Saxena S, Azzi A | title = Cloning of novel human SEC14p-like proteins: ligand binding and functional properties | journal = Free Radic. Biol. Med. | volume = 34 | issue = 11 | pages = 1458–72 | year = 2004 | pmid = 12757856 | doi = 10.1016/S0891-5849(03)00173-4 }}
  • {{cite journal | vauthors = Stocker A, Baumann U | title = Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis | journal = J. Mol. Biol. | volume = 332 | issue = 4 | pages = 759–65 | year = 2003 | pmid = 12972248 | doi = 10.1016/S0022-2836(03)00924-0 }}
  • {{cite journal | vauthors = Mokashi V, Singh DK, Porter TD | title = Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A | journal = Biochem. Biophys. Res. Commun. | volume = 316 | issue = 3 | pages = 688–92 | year = 2004 | pmid = 15033454 | doi = 10.1016/j.bbrc.2004.02.103 }}
  • {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biol. | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 }}
  • {{cite journal | vauthors = Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR | title = Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution | journal = Science | volume = 308 | issue = 5725 | pages = 1149–54 | year = 2005 | pmid = 15790807 | doi = 10.1126/science.1108625 }}
{{refend}}{{PDB Gallery|geneid=23541}}{{gene-22-stub}}
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