| 释义 |
- Function
- Clinical significance
- References
- Further reading
{{Infobox_gene}}Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.[1][2] Function SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM][2] Clinical significance A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.[3] References1. ^{{cite journal | vauthors = Püschel AW, Adams RH, Betz H | title = Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension | journal = Neuron | volume = 14 | issue = 5 | pages = 941–8 | date = Jun 1995 | pmid = 7748561 | pmc = | doi = 10.1016/0896-6273(95)90332-1 }}
2. ^1 {{cite web | title = Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64218| accessdate = }}
3. ^{{cite journal | vauthors = Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, Kashofer K, Nojima S, Leitner A, Zebisch A, Wölfler A, Hofer S, Gerger A, Lax S, Beham-Schmid C, Steinke V, Heitzer E, Geigl JB, Windpassinger C, Hoefler G, Speicher MR, Richard Boland C, Kumanogoh A, Sill H | title = Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X. | journal = Nature Communications| volume = 5 | issue = | pages = 5191 | date = Oct 2014 | pmid = 25307848 | pmc = 4214414| doi = 10.1038/ncomms6191 }}
{{Clear}}Further reading{{refbegin | 2}}- {{cite journal | vauthors = Kikutani H, Kumanogoh A | title = Semaphorins in interactions between T cells and antigen-presenting cells. | journal = Nat. Rev. Immunol. | volume = 3 | issue = 2 | pages = 159–67 | year = 2003 | pmid = 12563299 | doi = 10.1038/nri1003 }}
- {{cite journal | vauthors = Kumanogoh A, Kikutani H | title = Immune semaphorins: a new area of semaphorin research. | journal = J. Cell Sci. | volume = 116 | issue = Pt 17 | pages = 3463–70 | year = 2004 | pmid = 12893810 | doi = 10.1242/jcs.00674 }}
- {{cite journal | vauthors = Elhabazi A, Marie-Cardine A, Chabbert-de Ponnat I, Bensussan A, Boumsell L | title = Structure and function of the immune semaphorin CD100/SEMA4D. | journal = Crit. Rev. Immunol. | volume = 23 | issue = 1–2 | pages = 65–81 | year = 2004 | pmid = 12906260 | doi = 10.1615/CritRevImmunol.v23.i12.40 }}
- {{cite journal | vauthors = Kumanogoh A, Marukawa S, Suzuki K, Takegahara N, Watanabe C, Ch'ng E, Ishida I, Fujimura H, Sakoda S, Yoshida K, Kikutani H | title = Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. | journal = Nature | volume = 419 | issue = 6907 | pages = 629–33 | year = 2002 | pmid = 12374982 | doi = 10.1038/nature01037 }}
- {{cite journal | vauthors = Abid A, Ismail M, Mehdi SQ, Khaliq S | title = Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases. | journal = J. Med. Genet. | volume = 43 | issue = 4 | pages = 378–81 | year = 2006 | pmid = 16199541 | pmc = 2563224 | doi = 10.1136/jmg.2005.035055 }}
- {{cite journal | vauthors = Nkyimbeng-Takwi E, Chapoval SP | title = Biology and function of neuroimmune semaphorins 4A and 4D | journal = Immunol. Res. | volume = 50 | issue = 1 | pages = 10–21 | year = 2011 | pmid = 21203905 | pmc = 3366695 | doi = 10.1007/s12026-010-8201-y }}
- {{cite journal | vauthors = Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP | title = Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor | journal = BMC Immunol. | volume = 12| pages = 30 | year = 2011 | pmid = 21595947 | pmc = 3118960 | doi = 10.1186/1471-2172-12-30 }}
- {{cite journal | vauthors = Nkyimbeng-Takwi EH, Shanks K, Smith E, Iyer A, Lipsky MM, Detolla LJ, Kikutani H, Keegan AD, Chapoval SP | title = Neuroimmune semaphorin 4A downregulates the severity of allergic response | journal = Mucosal Immunol. | volume = 5 | issue = 4 | pages = 409–19 | year = 2012 | pmid = 22472774 | pmc = 3378810 | doi = 10.1038/mi.2012.18 }}
- {{cite journal | vauthors = Mogie G, Shanks K, Nkyimbeng-Takwi EH, Smith E, Davila E, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP | title = Neuroimmune semaphorin 4A as a drug and drug target for asthma | journal = Int. Immunopharmacol. | volume = 17 | issue = 3 | pages = 568–75 | year = 2013 | pmid = 23994348 | doi = 10.1016/j.intimp.2013.08.005 | pmc=3818409}}
- {{cite journal | vauthors = Chapoval SP | title = Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis | journal = Arthritis Res. Ther. | volume = 17 | pages = 313 | year = 2015 | pmid = 26542940 | pmc = 4635990 | doi = 10.1186/s13075-015-0846-4 }}
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