| 释义 |
- Genetics
- Molecular biology
- Notes
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.[1]{{PBB_Summary
| section_title =
| summary_text = SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM][2]
}}GeneticsThis protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain. Molecular biologyThis protein forms dimers. NotesThis protein acts as a receptor for the malaria parasite Plasmodium falciparum. See also- Cluster of differentiation
References1. ^{{cite web | title = Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8482| accessdate = }}
2. ^{{cite web | title = Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8482| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Xu X, Ng S, Wu ZL, etal |title=Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22428–34 |year= 1998 |pmid= 9712866 |doi=10.1074/jbc.273.35.22428 }}
- {{cite journal |vauthors=Lange C, Liehr T, Goen M, etal |title=New eukaryotic semaphorins with close homology to semaphorins of DNA viruses. |journal=Genomics |volume=51 |issue= 3 |pages= 340–50 |year= 1998 |pmid= 9721204 |doi= 10.1006/geno.1998.5256 }}
- {{cite journal |vauthors=Yamada A, Kubo K, Takeshita T, etal |title=Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 4094–100 |year= 1999 |pmid= 10201933 |doi= }}
- {{cite journal |vauthors=Angelisová P, Drbal K, Cerný J, etal |title=Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. |journal=Immunobiology |volume=200 |issue= 2 |pages= 234–45 |year= 1999 |pmid= 10416131 |doi= 10.1016/s0171-2985(99)80073-4}}
- {{cite journal |vauthors=Tamagnone L, Artigiani S, Chen H, etal |title=Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. |journal=Cell |volume=99 |issue= 1 |pages= 71–80 |year= 1999 |pmid= 10520995 |doi=10.1016/S0092-8674(00)80063-X }}
- {{cite journal |vauthors=Mine T, Harada K, Matsumoto T, etal |title=CDw108 expression during T-cell development. |journal=Tissue Antigens |volume=55 |issue= 5 |pages= 429–36 |year= 2000 |pmid= 10885563 |doi=10.1034/j.1399-0039.2000.550505.x }}
- {{cite journal |vauthors=Holmes S, Downs AM, Fosberry A, etal |title=Sema7A is a potent monocyte stimulator. |journal=Scand. J. Immunol. |volume=56 |issue= 3 |pages= 270–5 |year= 2002 |pmid= 12193228 |doi=10.1046/j.1365-3083.2002.01129.x }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Maurin JC, Delorme G, Machuca-Gayet I, etal |title=Odontoblast expression of semaphorin 7A during innervation of human dentin. |journal=Matrix Biol. |volume=24 |issue= 3 |pages= 232–8 |year= 2005 |pmid= 15907379 |doi= 10.1016/j.matbio.2005.03.005 }}
- {{cite journal |vauthors=Hu Y, Malone JP, Fagan AM, etal |title=Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. |journal=Mol. Cell. Proteomics |volume=4 |issue= 12 |pages= 2000–9 |year= 2006 |pmid= 16199891 |doi= 10.1074/mcp.M500207-MCP200 }}
- {{cite journal |vauthors=Koh JM, Oh B, Lee JY, etal |title=Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women. |journal=J. Hum. Genet. |volume=51 |issue= 2 |pages= 112–7 |year= 2006 |pmid= 16372136 |doi= 10.1007/s10038-005-0331-z }}
{{refend}}External links- {{MeshName|SEMA7A+protein,+human}}
- [https://www.ncbi.nlm.nih.gov/projects/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=jmh John Milton Hagen blood group system] in the BGMUT blood group antigen gene mutation database
{{NLM content}}{{Clusters of differentiation}}{{membrane-protein-stub}} 1 : Clusters of differentiation |