Semic may refer to:

• Semic Comics, a French comic book publisher
• Semic Press, a Swedish publishing company
• Semič
• Semić
• Semantic Interoperability Centre Europe (SEMIC.EU)

• The Great Coalition (Weimar Republic)
• The Great Cognito
• The Great Comic Relief Bake Off
• The Great Commandment (disambiguation)
• The Great Commission (band)
• The Great Commoner (disambiguation)
• The Great Conic Sections Rebellion
• The Great Conspiracy
• The Great Conspiracy (album)
• The Great Convergence
• The Great Council of Venice
• The Great Counterattack of King-Kong
• The Great Court Run
• The Great Crash
• The Great Cybernetic Depression
• The Great Dance of Argentina
• The Great Dawn
• The Great Dawn (1947 film)
• The Great Daylight 1972 Fireball
• The great day of Girona
• The Great Day of Girona
• The Great Debate
• The Great Debate (Canadian TV series)
• The Great Debates of 1858
• The Great Debate (TV series)