| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.[1][2][3] Function SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM][3] Interactions SENP2 has been shown to interact with NUP153.[1][4] References 1. ^1 {{cite journal | vauthors = Hang J, Dasso M | title = Association of the human SUMO-1 protease SENP2 with the nuclear pore | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 19961–6 | date = May 2002 | pmid = 11896061 | pmc = | doi = 10.1074/jbc.M201799200 }}
2. ^{{cite journal | vauthors = Nishida T, Kaneko F, Kitagawa M, Yasuda H | title = Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation | journal = J. Biol. Chem. | volume = 276 | issue = 42 | pages = 39060–6 | date = October 2001 | pmid = 11489887 | pmc = | doi = 10.1074/jbc.M103955200 }}
3. ^1 {{cite web | title = Entrez Gene: SENP2 SUMO1/sentrin/SMT3 specific peptidase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59343| accessdate = }}
4. ^{{cite journal | vauthors = Zhang H, Saitoh H, Matunis MJ | title = Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 18 | pages = 6498–508 | date = September 2002 | pmid = 12192048 | pmc = 135644 | doi = 10.1128/MCB.22.18.6498-6508.2002 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS | title = Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs | journal = J. Biol. Chem. | volume = 282 | issue = 36 | pages = 26217–24 | year = 2007 | pmid = 17591783 | doi = 10.1074/jbc.M702444200 }}
- {{cite journal | vauthors = Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS | title = Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family | journal = Biochem. J. | volume = 409 | issue = 2 | pages = 461–9 | year = 2008 | pmid = 17916063 | doi = 10.1042/BJ20070940 }}
- {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
- {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 1 | pages = 65–73 | year = 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }}
- {{cite journal | vauthors = Kadoya T, Yamamoto H, Suzuki T, Yukita A, Fukui A, Michiue T, Asahara T, Tanaka K, Asashima M, Kikuchi A | title = Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin | journal = Mol. Cell. Biol. | volume = 22 | issue = 11 | pages = 3803–19 | year = 2002 | pmid = 11997515 | pmc = 133821 | doi = 10.1128/MCB.22.11.3803-3819.2002 }}
- {{cite journal | vauthors = Zhang H, Saitoh H, Matunis MJ | title = Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 18 | pages = 6498–508 | year = 2002 | pmid = 12192048 | pmc = 135644 | doi = 10.1128/MCB.22.18.6498-6508.2002 }}
- {{cite journal | vauthors = Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI | title = SUMO-1 protease-1 regulates gene transcription through PML | journal = Mol. Cell | volume = 10 | issue = 4 | pages = 843–55 | year = 2002 | pmid = 12419228 | doi = 10.1016/S1097-2765(02)00699-8 }}
- {{cite journal | vauthors = Reverter D, Lima CD | title = A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex | journal = Structure | volume = 12 | issue = 8 | pages = 1519–31 | year = 2004 | pmid = 15296745 | doi = 10.1016/j.str.2004.05.023 }}
- {{cite journal | vauthors = Itahana Y, Yeh ET, Zhang Y | title = Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2 | journal = Mol. Cell. Biol. | volume = 26 | issue = 12 | pages = 4675–89 | year = 2006 | pmid = 16738331 | pmc = 1489137 | doi = 10.1128/MCB.01830-05 }}
- {{cite journal | vauthors = Reverter D, Lima CD | title = Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates | journal = Nat. Struct. Mol. Biol. | volume = 13 | issue = 12 | pages = 1060–8 | year = 2006 | pmid = 17099700 | doi = 10.1038/nsmb1168 }}
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