| 释义 |
- References
- Further reading
{{Infobox_gene}}Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003).[supplied by OMIM][3]
}}References1. ^{{cite journal | vauthors = Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT | title = NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins | journal = J Biol Chem | volume = 278 | issue = 28 | pages = 25637–43 |date=Jul 2003 | pmid = 12730221 | pmc = | doi = 10.1074/jbc.M212948200 }}
2. ^{{cite journal | vauthors = Gan-Erdene T, Nagamalleswari K, Yin L, Wu K, Pan ZQ, Wilkinson KD | title = Identification and characterization of DEN1, a deneddylase of the ULP family | journal = J Biol Chem | volume = 278 | issue = 31 | pages = 28892–900 |date=Jul 2003 | pmid = 12759362 | pmc = | doi = 10.1074/jbc.M302890200 }}
3. ^1 {{cite web | title = Entrez Gene: SENP8 SUMO/sentrin specific peptidase family member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=123228| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS |title=Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.|journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26217–24 |year= 2007 |pmid= 17591783 |doi=10.1074/jbc.M702444200 }}
- {{cite journal | vauthors=Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS |title=Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. |journal=Biochem. J. |volume=409 |issue= 2 |pages= 461–9 |year= 2008 |pmid= 17916063 |doi=10.1042/BJ20070940 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Wu K, Yamoah K, Dolios G, etal |title=DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28882–91 |year= 2003 |pmid= 12759363 |doi= 10.1074/jbc.M302888200 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Xirodimas DP, Saville MK, Bourdon JC, etal |title=Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. |journal=Cell |volume=118 |issue= 1 |pages= 83–97 |year= 2004 |pmid= 15242646 |doi= 10.1016/j.cell.2004.06.016 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Reverter D, Wu K, Erdene TG, etal |title=Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. |journal=J. Mol. Biol. |volume=345 |issue= 1 |pages= 141–51 |year= 2005 |pmid= 15567417 |doi= 10.1016/j.jmb.2004.10.022 }}
- {{cite journal |vauthors=Shen LN, Liu H, Dong C, etal |title=Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. |journal=EMBO J. |volume=24 |issue= 7 |pages= 1341–51 |year= 2005 |pmid= 15775960 |doi= 10.1038/sj.emboj.7600628 | pmc=1142549 }}
{{refend}}{{PDB Gallery|geneid=123228}}{{gene-15-stub}} |