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词条 SEPP1
释义

  1. References

  2. Further reading

{{Infobox_gene}}Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.[1][2]

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 9 Sec residues (human, rat, mouse - see Burk and Hill 2009) per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.[2]

References

1. ^{{cite journal | vauthors = Hill KE, Lloyd RS, Burk RF | title = Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 2 | pages = 537–41 |date=Feb 1993 | pmid = 8421687 | pmc = 45698 | doi =10.1073/pnas.90.2.537 }}
2. ^1 {{cite web | title = Entrez Gene: SEPP1 selenoprotein P, plasma, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6414| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Burk RF, Hill KE |title=Selenoprotein P. A selenium-rich extracellular glycoprotein |journal=J. Nutr. |volume=124 |issue= 10 |pages= 1891–7 |year= 1994 |pmid= 7931697 |doi= }}
  • {{cite journal | author=Mostert V |title=Selenoprotein P: properties, functions, and regulation |journal=Arch. Biochem. Biophys. |volume=376 |issue= 2 |pages= 433–8 |year= 2000 |pmid= 10775431 |doi= 10.1006/abbi.2000.1735 }}
  • {{cite journal |vauthors=Hill KE, Lloyd RS, Yang JG, etal |title=The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10050–3 |year= 1991 |pmid= 2037562 |doi= }}
  • {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors=Akesson B, Bellew T, Burk RF |title=Purification of selenoprotein P from human plasma |journal=Biochim. Biophys. Acta |volume=1204 |issue= 2 |pages= 243–9 |year= 1994 |pmid= 8142465 |doi= 10.1016/0167-4838(94)90014-0}}
  • {{cite journal | vauthors=Hill KE, Dasouki M, Phillips JA, Burk RF |title=Human selenoprotein P gene maps to 5q31 |journal=Genomics |volume=36 |issue= 3 |pages= 550–1 |year= 1997 |pmid= 8884283 |doi=10.1006/geno.1996.0505 }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors=Mostert V, Lombeck I, Abel J |title=A novel method for the purification of selenoprotein P from human plasma |journal=Arch. Biochem. Biophys. |volume=357 |issue= 2 |pages= 326–30 |year= 1998 |pmid= 9735174 |doi= 10.1006/abbi.1998.0809 }}
  • {{cite journal |vauthors=Saito Y, Hayashi T, Tanaka A, etal |title=Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2866–71 |year= 1999 |pmid= 9915822 |doi=10.1074/jbc.274.5.2866 }}
  • {{cite journal |vauthors=Koyama H, Omura K, Ejima A, etal |title=Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry |journal=Anal. Biochem. |volume=267 |issue= 1 |pages= 84–91 |year= 1999 |pmid= 9918658 |doi= 10.1006/abio.1998.2949 }}
  • {{cite journal | vauthors=Arteel GE, Franken S, Kappler J, Sies H |title=Binding of selenoprotein P to heparin: characterization with surface plasmon resonance |journal=Biol. Chem. |volume=381 |issue= 3 |pages= 265–8 |year= 2000 |pmid= 10782998 |doi=10.1515/BC.2000.034 }}
  • {{cite journal |vauthors=Hondal RJ, Ma S, Caprioli RM, etal |title=Heparin-binding histidine and lysine residues of rat selenoprotein P |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 15823–31 |year= 2001 |pmid= 11278668 |doi= 10.1074/jbc.M010405200 }}
  • {{cite journal |vauthors=Nishimura K, Matsumiya K, Tsujimura A, etal |title=Association of selenoprotein P with testosterone production in cultured Leydig cells |journal=Arch. Androl. |volume=47 |issue= 1 |pages= 67–76 |year= 2001 |pmid= 11442337 |doi=10.1080/01485010152104026 }}
  • {{cite journal |vauthors=Al-Taie OH, Seufert J, Mörk H, etal |title=A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency |journal=Eur. J. Hum. Genet. |volume=10 |issue= 9 |pages= 499–504 |year= 2003 |pmid= 12173025 |doi= 10.1038/sj.ejhg.5200811 }}
  • {{cite journal | vauthors=Saito Y, Takahashi K |title=Characterization of selenoprotein P as a selenium supply protein |journal=Eur. J. Biochem. |volume=269 |issue= 22 |pages= 5746–51 |year= 2003 |pmid= 12423375 |doi=10.1046/j.1432-1033.2002.03298.x }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
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1 : Selenoproteins
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