| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene.[1][2] Function This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.[2] References 1. ^{{cite journal | vauthors = Gu QP, Beilstein MA, Vendeland SC, Lugade A, Ream W, Whanger PD | title = Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species | journal = Gene | volume = 193 | issue = 2 | pages = 187–96 | date = July 1997 | pmid = 9256076 | pmc = | doi = 10.1016/S0378-1119(97)00113-3 }}
2. ^1 {{cite web | title = Entrez Gene: SEPW1 selenoprotein W, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6415| accessdate = }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Whanger PD | title = Selenoprotein W: a review | journal = Cellular and Molecular Life Sciences | volume = 57 | issue = 13-14 | pages = 1846–52 | date = December 2000 | pmid = 11215511 | doi = 10.1007/PL00000666 }}
- {{cite journal | vauthors = Yeh JY, Beilstein MA, Andrews JS, Whanger PD | title = Tissue distribution and influence of selenium status on levels of selenoprotein W | journal = FASEB Journal | volume = 9 | issue = 5 | pages = 392–6 | date = March 1995 | pmid = 7896009 | doi = }}
- {{cite journal | vauthors = Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB | title = A transcript map of the chromosome 19q-arm glioma tumor suppressor region | journal = Genomics | volume = 64 | issue = 1 | pages = 44–50 | date = February 2000 | pmid = 10708517 | doi = 10.1006/geno.1999.6101 }}
- {{cite journal | vauthors = Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN | title = Characterization of mammalian selenoproteomes | journal = Science | volume = 300 | issue = 5624 | pages = 1439–43 | date = May 2003 | pmid = 12775843 | doi = 10.1126/science.1083516 }}
- {{cite journal | vauthors = Bellingham J, Gregory-Evans K, Fox MF, Gregory-Evans CY | title = Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P | journal = Biochimica et Biophysica Acta | volume = 1627 | issue = 2-3 | pages = 140–6 | date = June 2003 | pmid = 12818432 | doi = 10.1016/s0167-4781(03)00078-2 }}
- {{cite journal | vauthors = Pagmantidis V, Bermano G, Villette S, Broom I, Arthur J, Hesketh J | title = Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon | journal = FEBS Letters | volume = 579 | issue = 3 | pages = 792–6 | date = January 2005 | pmid = 15670848 | doi = 10.1016/j.febslet.2004.12.042 }}
- {{cite journal | vauthors = Kim YJ, Chai YG, Ryu JC | title = Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion | journal = Biochemical and Biophysical Research Communications | volume = 330 | issue = 4 | pages = 1095–102 | date = May 2005 | pmid = 15823556 | doi = 10.1016/j.bbrc.2005.03.080 }}
{{refend}}{{protein-stub}} 1 : Selenoproteins |