Sergio Martínez may refer to:

• Sergio Martínez (boxer) (born 1975), Argentine boxer
• Sergio Martínez (cyclist) (1943-1979), Cuban Olympic cyclist
• Sergio Martínez (swimmer) (born 1936), Colombian Olympic swimmer
• Sergio Daniel Martínez (born 1969), Uruguayan football striker
• Sergio Castro Martínez (born 1941), Mexican humanitarian
• Sergio Martínez Ballesteros (born 1975), Spanish football defender

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