1. People with the surname

2. Fictional

Serio may refer to:

• Serio, Mexican American rapper from Los Angeles, California
• Sério, a municipality in Rio Grande do Sul, Brazil
• Serio (river), a river in Lombardy, Italy
• 11022 Serio, a main belt asteroid

People with the surname

• José Sério (1922–2010), Portuguese footballer
• Renato Serio (born 1946), Italian composer, conductor and arranger
• Steve Serio (born 1987), American wheelchair basketball player
• Augusto Leudo (born 1997), Colombian Mechatronics Engineer

Fictional

• Serio (HMX-13), a character from the visual novel To Heart

• 42nd Street-5th Avenue-Bryant Park (New York City Subway)
• 42nd Street (BMT Broadway Line)
• 42nd Street (BMT Broadway Line station)
• 42nd Street-Bryant Park
• 42nd Street-Bryant Park (IND Sixth Avenue Line)
• 42nd Street-Bryant Park (IND Sixth Avenue Line station)
• 42nd Street-Bryant Park (New York City Subway)
• 42nd Street Crosstown Line
• 42nd Street Crosstown Line (Manhattan)
• 42nd Street Ferry
• 42nd Street Ferry (Williamsburg)
• 42nd Street-Fifth Avenue-Bryant Park (New York City Subway)
• 42nd Street-Grand Central (IRT Flushing Line)
• 42nd Street-Grand Central (IRT Lexington Avenue Line)
• 42nd Street-Grand Central (New York City Subway)
• 42nd Street-Grand Central (New York City Subway station)
• 42nd Street (IND Eighth Avenue Line)
• 42nd Street (IND Sixth Avenue Line)
• 42nd Street (IND Sixth Avenue Line station)
• 42nd Street Line
• 42nd Street Line (IRT)
• 42nd Street Line (Manhattan)
• 42nd Street Line (surface)
• 42nd Street-Port Authority Bus Terminal
• 42nd Street-Port Authority Bus Terminal (IND Eighth Avenue Line)