| 词条 | Serotonin–dopamine releasing agent |
| 释义 |
A serotonin–dopamine releasing agent (SDRA) is a type of drug which induces the release of serotonin and dopamine in the body and/or brain. A closely related type of drug is a serotonin–dopamine reuptake inhibitor (SDRI). Examples of SDRAsA number of tryptamine derivatives have been found to act as SDRAs.[1] One such agent is 5-chloro-αMT (PAL-542), which has been reported as having about 64-fold selectivity for dopamine release over norepinephrine release and about 3-fold selectivity for serotonin release over dopamine release, making it a highly selective and well-balanced SDRA.[2] Another agent is 5-fluoro-αET (PAL-545), which has about 35-fold selectivity for dopamine release over norepinephrine release and about 4-fold selectivity for serotonin release over dopamine release.[1] Though selective for inducing the release of serotonin and dopamine over norepinephrine, these agents are not selective monoamine releasers; they have all also been found to be potent agonists of the 5-HT2A receptor, and may act as agonists of other serotonin receptors as well.[1] UWA-101 is an SDRI that, based on its chemical structure, may also have efficacy as a releasing agent of serotonin and dopamine.[3]See also
References1. ^1 2 {{cite journal |vauthors=Blough BE, Landavazo A, Partilla JS, etal | title = Alpha-ethyltryptamines as dual dopamine-serotonin releasers | journal = Bioorganic & Medicinal Chemistry Letters | volume = 24 | issue = 19 | pages = 4754–8 |date=October 2014 | pmid = 25193229 | doi = 10.1016/j.bmcl.2014.07.062 | url = http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(14)00786-0 | pmc=4211607}} {{Monoamine releasing agents}}{{TAAR ligands}}{{DEFAULTSORT:Serotonin-dopamine releasing agent}}{{pharmacology-stub}}2. ^{{cite journal |vauthors=Banks ML, Bauer CT, Blough BE, etal | title = Abuse-related effects of dual dopamine/serotonin releasers with varying potency to release norepinephrine in male rats and rhesus monkeys | journal = Experimental and Clinical Psychopharmacology | volume = 22 | issue = 3 | pages = 274–84 |date=June 2014 | pmid = 24796848 | doi = 10.1037/a0036595 | url = http://content.apa.org/journals/pha/22/3/274 | pmc=4067459}} 3. ^{{cite journal |vauthors=Johnston TH, Millar Z, Huot P, etal | title = A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates | journal = FASEB Journal | volume = 26 | issue = 5 | pages = 2154–63 |date=May 2012 | pmid = 22345403 | doi = 10.1096/fj.11-195016 | url = http://www.fasebj.org/cgi/pmidlookup?view=long&pmid=22345403}} 3 : Serotonin-dopamine releasing agents|TAAR1 agonists|VMAT inhibitors |
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