| 词条 | Setoperone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 449587261 | ImageFile=Setoperone.svg | ImageSize=250px | IUPACName=6-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-7-methyl-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-5-one | OtherNames= |Section1={{Chembox Identifiers | UNII_Ref = {{fdacite|correct|FDA}} | UNII = BQ67CS3Q3E | CASNo_Ref = {{cascite|correct|??}} | CASNo=86487-64-1 | PubChem=68604 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D02686 | SMILES=CC1=C(C(=O)N2CCSC2=N1)CCN3CCC(CC3)C(=O)C4=CC=C(C=C4)F | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 61870 | InChI = 1/C21H24FN3O2S/c1-14-18(20(27)25-12-13-28-21(25)23-14)8-11-24-9-6-16(7-10-24)19(26)15-2-4-17(22)5-3-15/h2-5,16H,6-13H2,1H3 | InChIKey = RBGAHDDQSRBDOG-UHFFFAOYAH | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C21H24FN3O2S/c1-14-18(20(27)25-12-13-28-21(25)23-14)8-11-24-9-6-16(7-10-24)19(26)15-2-4-17(22)5-3-15/h2-5,16H,6-13H2,1H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = RBGAHDDQSRBDOG-UHFFFAOYSA-N |Section2={{Chembox Properties | Formula=C21H24FN3O2S | MolarMass=401.50 g/mol | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }} Setoperone is a compound that is a ligand to the 5-HT2A receptor. It can be radiolabeled with the radioisotope fluorine-18 and used as a radioligand with positron emission tomography (PET). Several research studies have used the radiolabeled setoperone in neuroimaging for the studying neuropsychiatric disorders, such as depression[1] or schizophrenia.[2] References1. ^{{Cite journal| author = Jeffrey H. Meyer, Shitij Kapur, Sylvain Houle, Jean DaSilva, Beata Owczarek, Gregory M. Brown, Alan A. Wilson and Sidney H. Kennedy| title = Prefrontal Cortex 5-HT2 Receptors in Depression: An [18F]Setoperone PET Imaging Study| journal = American Journal of Psychiatry| volume = 156| pages = 1029–1034| url = http://ajp.psychiatryonline.org/cgi/content/full/156/7/1029| pmid = 10401447| issue = 7| date = July 1, 1999 | doi = 10.1176/ajp.156.7.1029| doi-broken-date = 2018-09-23}} {{Antipsychotics}}{{nervous-system-drug-stub}}2. ^{{Cite journal| author = Ralph Lewis, Shitij Kapur, Corey Jones, Jean DaSilva, Gregory M. Brown, Alan A. Wilson, Sylvain Houle and Robert B. Zipursky| title = Serotonin 5-HT2 Receptors in Schizophrenia: A PET Study Using [18F]Setoperone in Neuroleptic-Naive Patients and Normal Subjects| journal = American Journal of Psychiatry| volume = 156| pages = 72–78| url = http://ajp.psychiatryonline.org/cgi/content/abstract/156/1/72| pmid = 9892300| issue = 1| date = January 1, 1999 | doi = 10.1176/ajp.156.1.72}} 7 : 5-HT2A antagonists|Abandoned drugs|Aromatic ketones|Fluoroarenes|Piperidines|Receptor modulators|Thiazolopyrimidines |
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