请输入您要查询的百科知识：

　

词条 SF1 (gene)
释义

  1. Interactions

  2. References

  3. Further reading

{{Infobox gene}}Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.[1][2][3]

Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.[4]SF1 gene is necessary to make the bipotential gonad ; but while SF1 levels decline in the genital ridge of XX mouse embryos,the SF1 gene stays on the developing testes. SF 1 (transcription factor) appears to be active in masculining both the Leydig cells and Steroli cells. In Sterolic cells with the SOX9 protein it elevates the level of AMH transcription. In Leydig cells it activates the gene encoding the enzyme that make testosterone hormone.

Interactions

SF1 (gene) has been shown to interact with Ewing sarcoma breakpoint region 1,[5] U2AF2,[6][7][8] Testis determining factor,[9] and Transcription elongation regulator 1.[10]

References

1. ^{{cite journal | vauthors = Toda T, Iida A, Miwa T, Nakamura Y, Imai T | title = Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1) | journal = Hum Mol Genet | volume = 3 | issue = 3 | pages = 465–70 |date=Jul 1994 | pmid = 7912130 | pmc = | doi =10.1093/hmg/3.3.465 }}
2. ^{{cite journal | vauthors = Kramer A, Quentin M, Mulhauser F | title = Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene | journal = Gene | volume = 211 | issue = 1 | pages = 29–37 |date=Jun 1998 | pmid = 9573336 | pmc = | doi =10.1016/S0378-1119(98)00058-4 }}
3. ^{{cite web | title = Entrez Gene: SF1 splicing factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7536| accessdate = }}
4. ^{{cite journal | vauthors = Rino J, Desterro JM, Pacheco TR, Gadella TW, Carmo-Fonseca M | title = Splicing factors SF1 and U2AF associate in extraspliceosomal complexes | journal = Mol. Cell. Biol. | volume = 28 | issue = 9 | pages = 3045–57 |date=May 2008 | pmid = 18285458 | pmc = 2293075 | doi = 10.1128/MCB.02015-07 | url = | issn = }}
5. ^{{cite journal | vauthors = Zhang D, Paley AJ, Childs G | title = The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18086–91 |date=July 1998 | pmid = 9660765 | doi = 10.1074/jbc.273.29.18086| url = | issn = }}
6. ^{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 |date=October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | url = | issn = }}
7. ^{{cite journal | vauthors = Berglund JA, Abovich N, Rosbash M | title = A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition | journal = Genes Dev. | volume = 12 | issue = 6 | pages = 858–67 |date=March 1998 | pmid = 9512519 | pmc = 316625 | doi = 10.1101/gad.12.6.858| url = | issn = }}
8. ^{{cite journal | vauthors = Abovich N, Rosbash M | title = Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals | journal = Cell | volume = 89 | issue = 3 | pages = 403–12 |date=May 1997 | pmid = 9150140 | doi = 10.1016/S0092-8674(00)80221-4| url = | issn = }}
9. ^{{cite journal | vauthors = Kashimada K, Koopman P | title = Sry: the master switch in mammalian sex determination | journal = Development | volume = 137 | issue = 23 | pages = 3921–30 |date=December 2010 | pmid = 21062860 | doi = 10.1242/dev.048983 }}
10. ^{{cite journal | vauthors = Goldstrohm AC, Albrecht TR, Suñé C, Bedford MT, Garcia-Blanco MA | title = The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 | journal = Mol. Cell. Biol. | volume = 21 | issue = 22 | pages = 7617–28 |date=November 2001 | pmid = 11604498 | pmc = 99933 | doi = 10.1128/MCB.21.22.7617-7628.2001 | url = | issn = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | author=Krämer A |title=Purification of splicing factor SF1, a heat-stable protein that functions in the assembly of a presplicing complex. |journal=Mol. Cell. Biol. |volume=12 |issue= 10 |pages= 4545–52 |year= 1992 |pmid= 1406644 |doi= | pmc=360381 }}
  • {{cite journal | vauthors=Naumovski L, Cleary ML |title=The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M. |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3884–92 |year= 1996 |pmid= 8668206 |doi= | pmc=231385 }}
  • {{cite journal | vauthors=Arning S, Grüter P, Bilbe G, Krämer A |title=Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA. |journal=RNA |volume=2 |issue= 8 |pages= 794–810 |year= 1996 |pmid= 8752089 |doi= | pmc=1369416 }}
  • {{cite journal | vauthors=Abovich N, Rosbash M |title=Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. |journal=Cell |volume=89 |issue= 3 |pages= 403–12 |year= 1997 |pmid= 9150140 |doi=10.1016/S0092-8674(00)80221-4 }}
  • {{cite journal |vauthors=Caslini C, Spinelli O, Cazzaniga G, etal |title=Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins. |journal=Genomics |volume=42 |issue= 2 |pages= 268–77 |year= 1997 |pmid= 9192847 |doi= 10.1006/geno.1997.4705 }}
  • {{cite journal | vauthors=Zhang D, Childs G |title=Human ZFM1 protein is a transcriptional repressor that interacts with the transcription activation domain of stage-specific activator protein. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6868–77 |year= 1998 |pmid= 9506990 |doi=10.1074/jbc.273.12.6868 }}
  • {{cite journal | vauthors=Berglund JA, Abovich N, Rosbash M |title=A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. |journal=Genes Dev. |volume=12 |issue= 6 |pages= 858–67 |year= 1998 |pmid= 9512519 |doi=10.1101/gad.12.6.858 | pmc=316625 }}
  • {{cite journal | vauthors=Zhang D, Paley AJ, Childs G |title=The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18086–91 |year= 1998 |pmid= 9660765 |doi=10.1074/jbc.273.29.18086 }}
  • {{cite journal |vauthors=Neubauer G, King A, Rappsilber J, etal |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
  • {{cite journal |vauthors=Wang X, Bruderer S, Rafi Z, etal |title=Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly. |journal=EMBO J. |volume=18 |issue= 16 |pages= 4549–59 |year= 1999 |pmid= 10449420 |doi= 10.1093/emboj/18.16.4549 | pmc=1171529 }}
  • {{cite journal |vauthors=Lapteva N, Nieda M, Ando Y, etal |title=Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 4 |pages= 1059–65 |year= 2001 |pmid= 11467860 |doi= 10.1006/bbrc.2001.5215 }}
  • {{cite journal |vauthors=Goldstrohm AC, Albrecht TR, Suñé C, etal |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7617–28 |year= 2001 |pmid= 11604498 |doi= 10.1128/MCB.21.22.7617-7628.2001 | pmc=99933 }}
  • {{cite journal |vauthors=Liu Z, Luyten I, Bottomley MJ, etal |title=Structural basis for recognition of the intron branch site RNA by splicing factor 1. |journal=Science |volume=294 |issue= 5544 |pages= 1098–102 |year= 2001 |pmid= 11691992 |doi= 10.1126/science.1064719 }}
  • {{cite journal | vauthors=Rappsilber J, Ryder U, Lamond AI, Mann M |title=Large-scale proteomic analysis of the human spliceosome. |journal=Genome Res. |volume=12 |issue= 8 |pages= 1231–45 |year= 2002 |pmid= 12176931 |doi= 10.1101/gr.473902 | pmc=186633 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Selenko P, Gregorovic G, Sprangers R, etal |title=Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 965–76 |year= 2003 |pmid= 12718882 |doi=10.1016/S1097-2765(03)00115-1 }}
  • {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
  • {{cite journal | vauthors=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004 | pmc=517884 }}
{{refend}}{{PDB Gallery|geneid=7536}}{{gene-11-stub}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/13 8:55:25