“SGTA”的意思、由来-开放百科全书

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.^[1]^[2]^[3] SGTA orthologs ^[4] have also been identified in several mammals for which complete genome data are available.

Function

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.^[3]

Interactions

References

1. ^{{cite journal | vauthors = Kordes E, Savelyeva L, Schwab M, Rommelaere J, Jauniaux JC, Cziepluch C | title = Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans | journal = Genomics | volume = 52 | issue = 1 | pages = 90–4 | date = Aug 1998 | pmid = 9740675 | pmc = | doi = 10.1006/geno.1998.5385 }}
2. ^¹{{cite journal | vauthors = Schantl JA, Roza M, De Jong AP, Strous GJ | title = Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor | journal = The Biochemical Journal | volume = 373 | issue = Pt 3 | pages = 855–63 | date = Aug 2003 | pmid = 12735788 | pmc = 1223544 | doi = 10.1042/BJ20021591 }}
3. ^¹{{cite web | title = Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6449| accessdate = }}
4. ^{{cite web | title = OrthoMaM phylogenetic marker: SGTA coding sequence | url = http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000104969_SGTA.xml }}

Further reading

{{cite journal | vauthors = Roberts JD, Thapaliya A, Martínez-Lumbreras S, Krysztofinska EM, Isaacson RL | title = Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha | journal = Frontiers in Molecular Biosciences | volume = 2 | date = Dec 2015 | pmid = 26734616 | doi = 10.3389/fmolb.2015.00071 | pmc=4683186 | pages=71}}

{{cite journal | vauthors = Heavner GA, Audhya T, Goldstein G | title = Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines | journal = Regulatory Peptides | volume = 27 | issue = 2 | pages = 257–62 | date = Feb 1990 | pmid = 2158125 | doi = 10.1016/0167-0115(90)90044-W }}{{cite journal | vauthors = Geraghty RJ, Talbot KJ, Callahan M, Harper W, Panganiban AT | title = Cell type-dependence for Vpu function | journal = Journal of Medical Primatology | volume = 23 | issue = 2–3 | pages = 146–50 | year = 1994 | pmid = 7966229 | doi = 10.1111/j.1600-0684.1994.tb00115.x }}

{{cite journal | vauthors = Cziepluch C, Kordes E, Poirey R, Grewenig A, Rommelaere J, Jauniaux JC | title = Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1 | journal = Journal of Virology | volume = 72 | issue = 5 | pages = 4149–56 | date = May 1998 | pmid = 9557704 | pmc = 109644 | doi = }}

{{cite journal | vauthors = Callahan MA, Handley MA, Lee YH, Talbot KJ, Harper JW, Panganiban AT | title = Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family | journal = Journal of Virology | volume = 72 | issue = 6 | pages = 5189–97 | date = Jun 1998 | pmid = 9573291 | pmc = 110095 | doi = }}

{{cite journal | vauthors = Callahan MA, Handley MA, Lee YH, Talbot KJ, Harper JW, Panganiban AT | title = Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family | journal = Journal of Virology | volume = 72 | issue = 10 | pages = 8461 | date = Oct 1998 | pmid = 9766974 | pmc = 110251 | doi = }}

{{cite journal | vauthors = Liu FH, Wu SJ, Hu SM, Hsiao CD, Wang C | title = Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats | journal = The Journal of Biological Chemistry | volume = 274 | issue = 48 | pages = 34425–32 | date = Nov 1999 | pmid = 10567422 | doi = 10.1074/jbc.274.48.34425 }}

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}

{{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}

{{cite journal | vauthors = Handley MA, Paddock S, Dall A, Panganiban AT | title = Association of Vpu-binding protein with microtubules and Vpu-dependent redistribution of HIV-1 Gag protein | journal = Virology | volume = 291 | issue = 2 | pages = 198–207 | date = Dec 2001 | pmid = 11878889 | doi = 10.1006/viro.2001.1166 }}

{{cite journal | vauthors = Angeletti PC, Walker D, Panganiban AT | title = Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity | journal = Cell Stress & Chaperones | volume = 7 | issue = 3 | pages = 258–68 | date = Jul 2002 | pmid = 12482202 | pmc = 514826 | doi = 10.1379/1466-1268(2002)007<0258:SGRPVP>2.0.CO;2 }}

{{cite journal | vauthors = Pai MT, Yang CS, Tzeng SR, Wang C, Cheng JW | title = 1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT | journal = Journal of Biomolecular NMR | volume = 26 | issue = 4 | pages = 381–2 | date = Aug 2003 | pmid = 12815268 | doi = 10.1023/A:1024029117511 }}

{{cite journal | vauthors = Wang H, Zhang Q, Zhu D | title = hSGT interacts with the N-terminal region of myostatin | journal = Biochemical and Biophysical Research Communications | volume = 311 | issue = 4 | pages = 877–83 | date = Nov 2003 | pmid = 14623262 | doi = 10.1016/j.bbrc.2003.10.080 }}

{{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}

{{cite journal | vauthors = Winnefeld M, Rommelaere J, Cziepluch C | title = The human small glutamine-rich TPR-containing protein is required for progress through cell division | journal = Experimental Cell Research | volume = 293 | issue = 1 | pages = 43–57 | date = Feb 2004 | pmid = 14729056 | doi = 10.1016/j.yexcr.2003.09.028 }}

{{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}

1 : Co-chaperones