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词条 SH2B1
释义

  1. Interactions

  2. Clinical significance

  3. See also

  4. References

  5. Further reading

{{Infobox_gene}}SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.[1][2][3]

Interactions

SH2B1 has been shown to interact with:

  • Grb2,[4][5]
  • Insulin receptor,[2][5]
  • Janus kinase 2,[6][7] and
  • TrkA.[4][8]

Clinical significance

Variations close to or in the SH2B1 gene have been found to associatate with obesity in two very large genome wide association studies of body mass index (BMI).[9][10] Furthermore, SH2B1 deletions are associated with severe early-onset obesity.[11]

See also

  • Genetics of obesity

References

1. ^{{cite journal | vauthors = Kong M, Wang CS, Donoghue DJ | title = Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation | journal = J Biol Chem | volume = 277 | issue = 18 | pages = 15962–70 | date = Apr 2002 | pmid = 11827956 | pmc = | doi = 10.1074/jbc.M102777200 }}
2. ^1 {{cite journal | vauthors = Nelms K, O'Neill TJ, Li S, Hubbard SR, Gustafson TA, Paul WE | title = Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain | journal = Mamm Genome | volume = 10 | issue = 12 | pages = 1160–7 | date = Jan 2000 | pmid = 10594240 | pmc = | doi = 10.1007/s003359901183 | url = https://zenodo.org/record/1232697/files/article.pdf }}
3. ^{{cite web | title = Entrez Gene: SH2B1 SH2B adaptor protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25970| accessdate = }}
4. ^1 {{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | date = November 1998 | pmid = 9856458 | doi = 10.1016/s0896-6273(00)80620-0}}
5. ^1 {{cite journal | vauthors = Kotani K, Wilden P, Pillay TS | title = SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase | journal = Biochem. J. | volume = 335 | issue = 1| pages = 103–9 | date = October 1998 | pmid = 9742218 | pmc = 1219757 | doi = 10.1042/bj3350103 }}
6. ^{{cite journal | vauthors = Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C | title = Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling | journal = Mol. Cell. Biol. | volume = 17 | issue = 11 | pages = 6633–44 | date = November 1997 | pmid = 9343427 | pmc = 232517 | doi = 10.1128/mcb.17.11.6633}}
7. ^{{cite journal | vauthors = Xie S, Lin H, Sun T, Arlinghaus RB | title = Jak2 is involved in c-Myc induction by Bcr-Abl | journal = Oncogene | volume = 21 | issue = 47 | pages = 7137–46 | date = October 2002 | pmid = 12370803 | doi = 10.1038/sj.onc.1205942 }}
8. ^{{cite journal | vauthors = Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T | title = Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop | journal = FEBS Lett. | volume = 469 | issue = 1 | pages = 72–6 | date = March 2000 | pmid = 10708759 | doi = 10.1016/s0014-5793(00)01242-4}}
9. ^{{cite journal | vauthors = Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek AL, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, Kiemeney LA, Pedersen O, Kong A, Thorsteinsdottir U, Stefansson K | title = Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. | journal = Nat. Genet. | volume = 41 | issue = 1 | pages = 18–24 | date = January 2009 | pmid = 19079260 | doi = 10.1038/ng.274 }}
10. ^{{cite journal | vauthors = Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN | title = Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. | journal = Nat. Genet. | volume = 41 | issue = 1 | pages = 24–34 | date = January 2009 | pmid = 19079261 | pmc = 2695662 | doi = 10.1038/ng.287 }}
11. ^{{cite journal | vauthors = Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S, Hurles ME, Farooqi IS | title = Large, rare chromosomal deletions associated with severe early-onset obesity | journal = Nature | volume = 463 | issue = 7281 | pages = 666–70 | date = February 2010 | pmid = 19966786 | pmc = 3108883 | doi = 10.1038/nature08689 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C | title = Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. | journal = Mol. Cell. Biol. | volume = 17 | issue = 11 | pages = 6633–44 | year = 1997 | pmid = 9343427 | pmc = 232517 | doi = 10.1128/mcb.17.11.6633}}
  • {{cite journal | vauthors = Kotani K, Wilden P, Pillay TS | title = SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase. | journal = Biochem. J. | volume = 335 | issue = | pages = 103–9 | year = 1998 | pmid = 9742218 | pmc = 1219757 | doi = 10.1042/bj3350103 }}
  • {{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons. | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | year = 1999 | pmid = 9856458 | doi = 10.1016/S0896-6273(00)80620-0 }}
  • {{cite journal | vauthors = Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T | title = Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop. | journal = FEBS Lett. | volume = 469 | issue = 1 | pages = 72–6 | year = 2000 | pmid = 10708759 | doi = 10.1016/S0014-5793(00)01242-4 }}
  • {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. | journal = DNA Res. | volume = 7 | issue = 1 | pages = 65–73 | year = 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }}
  • {{cite journal | vauthors = Rui L, Gunter DR, Herrington J, Carter-Su C | title = Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta. | journal = Mol. Cell. Biol. | volume = 20 | issue = 9 | pages = 3168–77 | year = 2000 | pmid = 10757801 | pmc = 85611 | doi = 10.1128/MCB.20.9.3168-3177.2000 }}
  • {{cite journal | vauthors = O'Brien KB, O'Shea JJ, Carter-Su C | title = SH2-B family members differentially regulate JAK family tyrosine kinases. | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8673–81 | year = 2002 | pmid = 11751854 | doi = 10.1074/jbc.M109165200 }}
  • {{cite journal | vauthors = Ohtsuka S, Takaki S, Iseki M, Miyoshi K, Nakagata N, Kataoka Y, Yoshida N, Takatsu K, Yoshimura A | title = SH2-B is required for both male and female reproduction. | journal = Mol. Cell. Biol. | volume = 22 | issue = 9 | pages = 3066–77 | year = 2002 | pmid = 11940664 | pmc = 133757 | doi = 10.1128/MCB.22.9.3066-3077.2002 }}
  • {{cite journal | vauthors = Xie S, Lin H, Sun T, Arlinghaus RB | title = Jak2 is involved in c-Myc induction by Bcr-Abl. | journal = Oncogene | volume = 21 | issue = 47 | pages = 7137–46 | year = 2002 | pmid = 12370803 | doi = 10.1038/sj.onc.1205942 }}
  • {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2003 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
  • {{cite journal | vauthors = O'Brien KB, Argetsinger LS, Diakonova M, Carter-Su C | title = YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling. | journal = J. Biol. Chem. | volume = 278 | issue = 14 | pages = 11970–8 | year = 2003 | pmid = 12551917 | doi = 10.1074/jbc.M210765200 }}
  • {{cite journal | vauthors = Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE | title = Kinase activation through dimerization by human SH2-B. | journal = Mol. Cell. Biol. | volume = 25 | issue = 7 | pages = 2607–21 | year = 2005 | pmid = 15767667 | pmc = 1061652 | doi = 10.1128/MCB.25.7.2607-2621.2005 }}
  • {{cite journal | vauthors = Donatello S, Fiorino A, Degl'Innocenti D, Alberti L, Miranda C, Gorla L, Bongarzone I, Rizzetti MG, Pierotti MA, Borrello MG | title = SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling. | journal = Oncogene | volume = 26 | issue = 45 | pages = 6546–59 | year = 2007 | pmid = 17471236 | doi = 10.1038/sj.onc.1210480 }}
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