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词条 SH2B2
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.[1][2]

Function

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[2]

Interactions

SH2B2 has been shown to interact with TrkA[3] and Cbl gene.[4][5]

References

1. ^{{cite journal | vauthors = Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A | title = Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation | journal = Oncogene | volume = 15 | issue = 1 | pages = 7–15 | date = Aug 1997 | pmid = 9233773 | pmc = | doi = 10.1038/sj.onc.1201163 }}
2. ^1 {{cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = }}
3. ^{{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | date = Nov 1998 | pmid = 9856458 | doi = 10.1016/S0896-6273(00)80620-0 }}
4. ^{{cite journal | vauthors = Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl | journal = Leukemia | volume = 13 | issue = 5 | pages = 760–7 | date = May 1999 | pmid = 10374881 | doi = 10.1038/sj/leu/2401397 }}
5. ^{{cite journal | vauthors = Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J | title = Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates | journal = EMBO J. | volume = 27 | issue = 5 | pages = 804–16 | date = Mar 2008 | pmid = 18273061 | pmc = 2265755 | doi = 10.1038/emboj.2008.18 }}
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Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A | title = Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes | journal = Genome Res. | volume = 8 | issue = 10 | pages = 1060–73 | year = 1998 | pmid = 9799793 | pmc = 310788 | doi = 10.1101/gr.8.10.1060 }}
  • {{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | year = 1999 | pmid = 9856458 | doi = 10.1016/S0896-6273(00)80620-0 }}
  • {{cite journal | vauthors = Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis | journal = Oncogene | volume = 18 | issue = 3 | pages = 759–67 | year = 1999 | pmid = 9989826 | doi = 10.1038/sj.onc.1202326 }}
  • {{cite journal | vauthors = Moodie SA, Alleman-Sposeto J, Gustafson TA | title = Identification of the APS protein as a novel insulin receptor substrate | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11186–93 | year = 1999 | pmid = 10196204 | doi = 10.1074/jbc.274.16.11186 }}
  • {{cite journal | vauthors = Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl | journal = Leukemia | volume = 13 | issue = 5 | pages = 760–7 | year = 1999 | pmid = 10374881 | doi = 10.1038/sj/leu/2401397 }}
  • {{cite journal | vauthors = Iseki M, Takaki S, Takatsu K | title = Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins | journal = Biochem. Biophys. Res. Commun. | volume = 272 | issue = 1 | pages = 45–54 | year = 2000 | pmid = 10872802 | doi = 10.1006/bbrc.2000.2736 }}
  • {{cite journal | vauthors = O'Brien KB, O'Shea JJ, Carter-Su C | title = SH2-B family members differentially regulate JAK family tyrosine kinases | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8673–81 | year = 2002 | pmid = 11751854 | doi = 10.1074/jbc.M109165200 }}
  • {{cite journal | vauthors = Liu J, Kimura A, Baumann CA, Saltiel AR | title = APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes | journal = Mol. Cell. Biol. | volume = 22 | issue = 11 | pages = 3599–609 | year = 2002 | pmid = 11997497 | pmc = 133825 | doi = 10.1128/MCB.22.11.3599-3609.2002 }}
  • {{cite journal | vauthors = Yabana N, Shibuya M | title = Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity | journal = Oncogene | volume = 21 | issue = 50 | pages = 7720–9 | year = 2002 | pmid = 12400014 | doi = 10.1038/sj.onc.1205927 }}
  • {{cite journal | vauthors = Ahn MY, Katsanakis KD, Bheda F, Pillay TS | title = Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling | journal = J. Biol. Chem. | volume = 279 | issue = 20 | pages = 21526–32 | year = 2004 | pmid = 15031295 | doi = 10.1074/jbc.M307740200 }}
  • {{cite journal | vauthors = Wilcox A, Katsanakis KD, Bheda F, Pillay TS | title = Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex | journal = J. Biol. Chem. | volume = 279 | issue = 37 | pages = 38881–8 | year = 2004 | pmid = 15231829 | doi = 10.1074/jbc.M406101200 }}
  • {{cite journal | vauthors = Hu J, Hubbard SR | title = Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins | journal = J. Biol. Chem. | volume = 280 | issue = 19 | pages = 18943–9 | year = 2005 | pmid = 15737992 | doi = 10.1074/jbc.M414157200 }}
  • {{cite journal | vauthors = Iseki M, Kubo-Akashi C, Kwon SM, Yamaguchi A, Takatsu K, Takaki S | title = APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation | journal = Biochem. Biophys. Res. Commun. | volume = 330 | issue = 3 | pages = 1005–13 | year = 2005 | pmid = 15809095 | doi = 10.1016/j.bbrc.2005.03.073 }}
  • {{cite journal | vauthors = Katsanakis KD, Pillay TS | title = Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588 | journal = J. Biol. Chem. | volume = 280 | issue = 45 | pages = 37827–32 | year = 2006 | pmid = 16141217 | doi = 10.1074/jbc.M505959200 }}
  • {{cite journal | vauthors = Li M, Li Z, Morris DL, Rui L | title = Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling | journal = Endocrinology | volume = 148 | issue = 4 | pages = 1615–21 | year = 2007 | pmid = 17204555 | doi = 10.1210/en.2006-1010 | pmc = 4710543 }}
{{refend}}{{PDB Gallery|geneid=10603}}{{protein-stub}}
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