“SHANK2”的意思、由来-开放百科全书

Function

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.^[2]

It is thought that SHANK2 might play a role in synaptogenesis by attaching metabotropic glutamate receptors (mGluRs) to an existing pool of NMDA receptors (NMDA-R), bylinking to the NMDA-R through PSD-95, and the mGluRs through HOMER1.^[3] An alternative hypothesis is that the Homer/Shank/GKAP/PSD-95 assembly mediates physical association of the NMDAR with IP3R/RYR and intracellular Ca2+ stores.

Interactions

References

1. ^{{cite journal | vauthors = Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, Kim E | title = Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development | journal = J Biol Chem | volume = 274 | issue = 41 | pages = 29510–8 | date = November 1999 | pmid = 10506216 | pmc = | doi = 10.1074/jbc.274.41.29510 }}
2. ^¹²{{cite web | title = Entrez Gene: SHANK2 SH3 and multiple ankyrin repeat domains 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22941| accessdate = }}
3. ^{{cite journal | vauthors = Boeckers TM, Bockmann J, Kreutz MR, Gundelfinger ED | title = ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease | journal = J. Neurochem. | volume = 81 | issue = 5 | pages = 903–10 | date = June 2002 | pmid = 12065602 | doi = 10.1046/j.1471-4159.2002.00931.x | url = | issn = }}
4. ^{{cite journal | vauthors = Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E | title = The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42 | journal = J. Biol. Chem. | volume = 278 | issue = 21 | pages = 19220–9 | date = May 2003 | pmid = 12626503 | doi = 10.1074/jbc.M301052200 | authorlink = }}
5. ^{{cite journal | vauthors = Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT | title = Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons | journal = Mol. Cell. Biol. | volume = 18 | issue = 10 | pages = 5838–51 | date = October 1998 | pmid = 9742101 | pmc = 109170 | authorlink = }}
6. ^¹{{cite journal | vauthors = Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M | title = Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein | journal = J. Neurosci. | volume = 20 | issue = 12 | pages = 4524–34 | date = June 2000 | pmid = 10844022 | authorlink = }}
7. ^¹{{cite journal | vauthors = Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, Gundelfinger ED | title = Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family | journal = Biochem. Biophys. Res. Commun. | volume = 264 | issue = 1 | pages = 247–52 | date = October 1999 | pmid = 10527873 | doi = 10.1006/bbrc.1999.1489 | authorlink = }}
8. ^{{cite journal | vauthors = Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB | title = Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton | journal = J. Biol. Chem. | volume = 276 | issue = 51 | pages = 48458–65 | date = Dec 2001 | pmid = 11583995 | pmc = 2715172 | doi = 10.1074/jbc.M104927200 | authorlink = }}

Further reading

{{cite journal | vauthors = Sheng M, Kim E | title = The Shank family of scaffold proteins. | journal = J. Cell Sci. | volume = ( Pt 11) | issue = | pages = 1851–6 | year = 2000 | pmid = 10806096 | doi = | series = 113 }}

{{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction. | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}

{{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing. | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}

{{cite journal | vauthors = Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT | title = Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. | journal = Mol. Cell. Biol. | volume = 18 | issue = 10 | pages = 5838–51 | year = 1998 | pmid = 9742101 | pmc = 109170 | doi = }}

{{cite journal | vauthors = Zitzer H, Richter D, Kreienkamp HJ | title = Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1. | journal = J. Biol. Chem. | volume = 274 | issue = 26 | pages = 18153–6 | year = 1999 | pmid = 10373412 | doi = 10.1074/jbc.274.26.18153 }}

{{cite journal | vauthors = Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF | title = Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. | journal = Neuron | volume = 23 | issue = 3 | pages = 583–92 | year = 1999 | pmid = 10433269 | doi = 10.1016/S0896-6273(00)80810-7 }}

{{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | journal = DNA Res. | volume = 6 | issue = 3 | pages = 197–205 | year = 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}

{{cite journal | vauthors = Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, Gundelfinger ED | title = Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. | journal = Biochem. Biophys. Res. Commun. | volume = 264 | issue = 1 | pages = 247–52 | year = 1999 | pmid = 10527873 | doi = 10.1006/bbrc.1999.1489 }}

{{cite journal | vauthors = Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM | title = The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. | journal = J. Biol. Chem. | volume = 275 | issue = 42 | pages = 32387–90 | year = 2000 | pmid = 10964907 | doi = 10.1074/jbc.C000490200 }}

{{cite journal | vauthors = Kreienkamp HJ, Zitzer H, Richter D | title = Identification of proteins interacting with the rat somatostatin receptor subtype 2 | journal = J. Physiol. Paris | volume = 94 | issue = 3–4 | pages = 193–8 | year = 2001 | pmid = 11087996 | doi = 10.1016/S0928-4257(00)00204-7 }}

{{cite journal | vauthors = Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB | title = Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. | journal = J. Biol. Chem. | volume = 276 | issue = 51 | pages = 48458–65 | year = 2002 | pmid = 11583995 | pmc = 2715172 | doi = 10.1074/jbc.M104927200 }}

{{cite journal | vauthors = Soltau M, Richter D, Kreienkamp HJ | title = The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. | journal = Mol. Cell. Neurosci. | volume = 21 | issue = 4 | pages = 575–83 | year = 2003 | pmid = 12504591 | doi = 10.1006/mcne.2002.1201 }}

{{cite journal | vauthors = Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E | title = The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. | journal = J. Biol. Chem. | volume = 278 | issue = 21 | pages = 19220–9 | year = 2003 | pmid = 12626503 | doi = 10.1074/jbc.M301052200 }}

{{cite journal | vauthors = Han W, Kim KH, Jo MJ, Lee JH, Yang J, Doctor RB, Moe OW, Lee J, Kim E, Lee MG | title = Shank2 associates with and regulates Na+/H+ exchanger 3. | journal = J. Biol. Chem. | volume = 281 | issue = 3 | pages = 1461–9 | year = 2006 | pmid = 16293618 | doi = 10.1074/jbc.M509786200 }}

{{cite journal | vauthors = Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y | title = Human chromosome 11 DNA sequence and analysis including novel gene identification. | journal = Nature | volume = 440 | issue = 7083 | pages = 497–500 | year = 2006 | pmid = 16554811 | doi = 10.1038/nature04632 }}