“Shelphs”的意思、由来-开放百科全书

The prototypic member of the group, a phosphatase from a psychrophilic bacterium Shewanella, has been studied as a model to understand the mechanisms that contribute to the high catalytic efficiency of enzymes from organisms adapted to low temperatures.^[5]^[6] Although PPP phosphatases in general are serine/threonine specific,^[1] Shewanella phosphatase is tyrosine specific.^[5] One of the two Shelph isoforms in plants is predicted to be located in the chloroplast.^[4]

Due to the absence of Shelphs in humans, these phosphatases have recently attracted attention as potential targets for new antiparasitic drug discovery.^[7]^[8]^[9]

References

1. ^¹²{{cite journal |author=Cohen PT |title=Novel protein serine/threonine phosphatases: variety is the spice of life |journal=Trends in Biochemical Sciences |volume=22 |issue=7 |pages=245–51 |date=July 1997 |pmid=9255065 |doi=10.1016/S0968-0004(97)01060-8}}
2. ^{{cite journal |vauthors=Andreeva AV, Kutuzov MA |title=PPP family of protein Ser/Thr phosphatases: two distinct branches? |journal=Molecular Biology and Evolution |volume=18 |issue=3 |pages=448–52 |date=1 March 2001|pmid=11230548 |url=http://mbe.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11230548 |doi=10.1093/oxfordjournals.molbev.a003823}}
3. ^{{cite journal |vauthors=Farkas I, Dombrádi V, Miskei M, Szabados L, Koncz C |title=Arabidopsis PPP family of serine/threonine phosphatases |journal=Trends in Plant Science |volume=12 |issue=4 |pages=169–76 |date=April 2007 |pmid=17368080 |doi=10.1016/j.tplants.2007.03.003|url=http://edoc.mpg.de/315220 }}
4. ^¹{{cite journal |vauthors=Andreeva AV, Kutuzov MA |title=Widespread presence of "bacterial-like" PPP phosphatases in eukaryotes |journal=BMC Evolutionary Biology |volume=4|pages=47 |date=November 2004 |pmid=15555063 |pmc=535813 |doi=10.1186/1471-2148-4-47}}
5. ^¹{{cite journal |vauthors=Tsuruta H, Aizono Y |title=Cloning of phosphatase I gene from a psychrophile, Shewanella sp., and some properties of the recombinant enzyme |journal=Journal of Biochemistry |volume=127 |issue=1 |pages=143–9 |date=January 2000 |pmid=10731677 |url=http://jb.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=10731677 |doi=10.1093/oxfordjournals.jbchem.a022576}}
6. ^{{cite journal |vauthors=Tsuruta H, Mikami B, Yamamoto C, Yamagata H |title=The role of group bulkiness in the catalytic activity of psychrophile cold-active protein tyrosine phosphatase |journal=The FEBS Journal |volume=275 |issue=17 |pages=4317–28 |date=September 2008 |pmid=18647345 |doi=10.1111/j.1742-4658.2008.06575.x}}
7. ^{{cite journal |vauthors=Kutuzov MA, Andreeva AV |title=Protein Ser/Thr phosphatases of parasitic protozoa |journal=Molecular and Biochemical Parasitology |volume=161 |issue=2 |pages=81–90 |date=October 2008 |pmid=18619495 |doi=10.1016/j.molbiopara.2008.06.008}}
8. ^{{cite journal |vauthors=Wilkes JM, Doerig C |title=The protein-phosphatome of the human malaria parasite Plasmodium falciparum |journal=BMC Genomics |volume=9|pages=412 |year=2008 |pmid=18793411 |pmc=2559854 |doi=10.1186/1471-2164-9-412}}
9. ^{{cite journal |vauthors=Bajsa J, Duke SO, Tekwani BL |title=Plasmodium falciparum serine/threonine phoshoprotein phosphatases (PPP): from housekeeper to the 'holy grail' |journal=Current Drug Targets |volume=9 |issue=11 |pages=997–1012 |date=November 2008 |pmid=18991611 |doi=10.2174/138945008786786055}}