| 词条 | Meclofenoxate |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 451505829 | IUPAC_name = 2-Dimethylaminoethyl (4-chlorophenoxy)acetate | image = Meclofenoxate.svg | width = 250 | tradename = | Drugs.com = {{drugs.com|international|meclofenoxate}} | legal_US = Not FDA approved | legal_status = Rx-only | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 51-68-3 | ATC_prefix = N06 | ATC_suffix = BX01 | PubChem = 4039 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | UNII_Ref = {{fdacite|correct|FDA}} | UNII = C76QQ2I0RG | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D00993 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 3899 | C=12 | H=16 | Cl=1 | N=1 | O=3 | smiles = Clc1ccc(cc1)OCC(=O)OCCN(C)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C12H16ClNO3/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11/h3-6H,7-9H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = XZTYGFHCIAKPGJ-UHFFFAOYSA-N }} Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease.[1][2][3] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). In elderly patients, meclofenoxate has been found clinically to improve memory, have a mentally stimulating effect, and improve general cognition.[4] Meclofenoxate also increases cellular membrane phospholipids.{{Citation needed|date=August 2010}} It is sold in Japan and some European countries, such as Germany, Hungary, and Austria, as a prescription drug.[3] Side effectsMeclofenoxate is considered to be very safe and high in tolerability.[3] However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.[3] ResearchMeclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 30–50%.[5] Brand namesIn addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.[6] See also
References1. ^{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA758|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=758–}} {{Nootropics}}{{Antidementia}}{{Acetylcholine receptor modulators}}2. ^{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA636|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=636–}} 3. ^1 2 3 {{cite book|author=Maija Haavisto|title=Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia|url=https://books.google.com/books?id=kopNAgAAQBAJ&pg=PA167|date=1 May 2008|publisher=Lulu.com|isbn=978-1-4092-0335-3|pages=167–}} 4. ^{{cite journal | doi = 10.1093/ageing/6.2.123 | last1 = Marcer | first1 = D | last2 = Hopkins | first2 = SM | title = The differential effects of meclofenoxate on memory loss in the elderly | journal = Age and Ageing | volume = 6 | issue = 2 | pages = 123–31 | year = 1977 | pmid = 329662}} 5. ^{{cite book|title=The Science of Anti-aging Medicine|url=https://books.google.com/books?id=RI8ZyNo5KCkC&pg=PA66|date=1 January 2003|publisher=American Academy of Anti-Aging Med|isbn=978-0-9668937-3-1|pages=66–}} 6. ^{{cite book|author=Yong Zhou|title=Drugs in Psychiatric Practice|url=https://books.google.com/books?id=6gglBQAAQBAJ|date=22 October 2013|publisher=Elsevier|isbn=978-1-4831-9193-5}} 7 : Amines|Antidementia agents|Carboxylate esters|Chloroarenes|Cholinergics|Nootropics|Phenol ethers |
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