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词条 SHOC2
释义

  1. Interactions

  2. References

  3. Further reading

{{Infobox_gene}}Leucine-rich repeat protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene.[1][2][3][4] Mutations that result in lipidation (specifically Myristoylation) of SHOC2 can cause Noonan syndrome.[5]

Interactions

SHOC2 has been shown to interact with C-Raf[3] and HRAS.[3]

References

1. ^{{cite journal | vauthors = Selfors LM, Schutzman JL, Borland CZ, Stern MJ | title = soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 12 | pages = 6903–8 | date = Jul 1998 | pmid = 9618511 | pmc = 22679 | doi = 10.1073/pnas.95.12.6903 }}
2. ^{{cite journal | vauthors = Sieburth DS, Sun Q, Han M | title = SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans | journal = Cell | volume = 94 | issue = 1 | pages = 119–30 | date = Aug 1998 | pmid = 9674433 | pmc = | doi = 10.1016/S0092-8674(00)81227-1 }}
3. ^{{cite journal | vauthors = Li W, Han M, Guan KL | title = The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf | journal = Genes Dev. | volume = 14 | issue = 8 | pages = 895–900 | date = May 2000 | pmid = 10783161 | pmc = 316541 | doi = }}
4. ^{{cite web | title = Entrez Gene: SHOC2 soc-2 suppressor of clear homolog (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8036| accessdate = }}
5. ^{{cite journal | vauthors = Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M | title = Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair | journal = Nature Genetics | volume = 41 | issue = 9 | pages = 1022–6 | date = Sep 2009 | pmid = 19684605 | doi = 10.1038/ng.425 | pmc=2765465}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Dai P, Xiong WC, Mei L | title = Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex | journal = J. Biol. Chem. | volume = 281 | issue = 2 | pages = 927–33 | year = 2006 | pmid = 16301319 | doi = 10.1074/jbc.M507360200 }}
  • {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 6 | pages = 355–64 | year = 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 }}
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