| 词条 | SHROOM3 |
| 释义 |
Protein shroom3 is a PDZ domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. Clinical relevanceMutations in this gene have been shown to cause heterotaxy.[4] A similar protein in mice is required for proper neurulation,[1][3] eye,[5] and gut development.[6][7] References1. ^1 {{cite journal | vauthors = Hildebrand JD, Soriano P | title = Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice | journal = Cell | volume = 99 | issue = 5 | pages = 485–97 | year = 1999 | pmid = 10589677 | pmc = | doi = 10.1016/S0092-8674(00)81537-8 }} 2. ^{{cite journal | vauthors = Hagens O, Ballabio A, Kalscheuer V, Kraehenbuhl JP, Schiaffino MV, Smith P, Staub O, Hildebrand J, Wallingford JB | title = A new standard nomenclature for proteins related to Apx and Shroom | journal = BMC Cell Biol | volume = 7 | issue = 1| pages = 18 | year = 2006 | pmid = 16615870 | pmc = 1481537 | doi = 10.1186/1471-2121-7-18 }} 3. ^1 {{cite web | title = Entrez Gene: SHROOM3 shroom family member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57619| accessdate = }} 4. ^{{cite journal | vauthors = Tariq M, Belmont JW, Lalani S, Smolarek T, Ware SM | title = SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing | journal = Genome Biol. | volume = 12 | issue = 9 | pages = R91 | year = 2011 | pmid = 21936905 | pmc = 3308054 | doi = 10.1186/gb-2011-12-9-r91 }} 5. ^{{cite journal | vauthors = Plageman TF, Chung MI, Lou M, Smith AN, Hildebrand JD, Wallingford JB, Lang RA | title = Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. | journal = Development | volume = 137 | issue = 3 | pages = 405–15 | year = 2010 | pmid = 20081189 | doi=10.1242/dev.045369 | pmc=2858910}} 6. ^{{cite journal | vauthors = Grosse AS, Pressprich MF, Curley LB, Hamilton KL, Margolis B, Hildebrand JD, Gumucio DL | title = Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. | journal = Development | volume = 138 | issue = 20 | pages = 4423–32 | year = 2011 | pmid = 21880782 | doi=10.1242/dev.065789 | pmc=3177312}} 7. ^{{cite journal | vauthors = Plageman TF, Zacharias AL, Gage PJ, Lang RA | title = Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis. | journal = Developmental Biology | volume = 357 | issue = 1 | pages = 227–34 | year = 2011 | pmid = 21726547 | doi=10.1016/j.ydbio.2011.06.027 | pmc=3619216}} Further reading{{refbegin | 2}}
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