| 词条 | SIRPB1 |
| 释义 |
Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[1][2][3] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B). {{PBB_Summary| section_title = | summary_text = The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[3] }} InteractionsSIRPB1 has been shown to interact with TYROBP.[4][5] References1. ^{{cite journal |author1=Kharitonenkov A |author2=Chen Z |author3=Sures I |author4=Wang H |author5=Schilling J |author6=Ullrich A | title = A family of proteins that inhibit signalling through tyrosine kinase receptors | journal = Nature | volume = 386 | issue = 6621 | pages = 181–6 |date=April 1997 | pmid = 9062191 | pmc = | doi = 10.1038/386181a0 |bibcode=1997Natur.386..181K }} 2. ^{{cite journal |author1=van den Berg TK |author2=van Beek EM |author3=Buhring HJ |author4=Colonna M |author5=Hamaguchi M |author6=Howard CJ |author7=Kasuga M |author8=Liu Y |author9=Matozaki T |author10=Neel BG |author11=Parkos CA |author12=Sano S |author13=Vignery A |author14=Vivier E |author15=Wright M |author16=Zawatzky R |author17=Barclay AN | title = A nomenclature for signal regulatory protein family members | journal = J Immunol | volume = 175 | issue = 12 | pages = 7788–9 |date=December 2005 | pmid = 16339511 | pmc = | doi = 10.4049/jimmunol.175.12.7788}} 3. ^1 {{cite web | title = Entrez Gene: SIRPB1 signal-regulatory protein beta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10326| accessdate = }} 4. ^{{cite journal |last=Dietrich |first=J |authorlink= |author2=Cella M |author3=Seiffert M |author4=Bühring H J |author5=Colonna M |date=January 2000 |title=Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells |journal=J. Immunol. |volume=164 |issue=1 |pages=9–12 |publisher= |location = UNITED STATES| issn = 0022-1767| pmid = 10604985 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.4049/jimmunol.164.1.9}} 5. ^{{cite journal |last=Tomasello |first=E |authorlink= |author2=Cant C |author3=Bühring H J |author4=Vély F |author5=André P |author6=Seiffert M |author7=Ullrich A |author8=Vivier E |date=August 2000 |title=Association of signal-regulatory proteins beta with KARAP/DAP-12 |journal=Eur. J. Immunol. |volume=30 |issue=8 |pages=2147–56 |publisher= |location = GERMANY| issn = 0014-2980| pmid = 10940905 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1 }} Further reading{{refbegin | 2}}
External links
1 : Clusters of differentiation |
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