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词条 Sirtuin 4
释义

  1. Function

  2. References

  3. Further reading

{{Infobox_gene}}Sirtuin 4, also known as SIRT4, is a protein which in humans is encoded by the SIRT4 gene.[1][2]

Function

This gene encodes a member of the sirtuin family of proteins which are homologs of the Sir2 gene in budding yeast. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been fully determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.[3] Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.[1][3] The protein encoded by this gene is included in class IV of the sirtuin family.[2]

SIRT4 is a mitochondrial ADP-ribosyltransferase that inhibits mitochondrial glutamate dehydrogenase 1 activity, thereby downregulating insulin secretion in response to amino acids.[4] It has been shown that SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells.[5]

References

1. ^1 {{cite journal | author = Frye RA | title = Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity | journal = Biochem. Biophys. Res. Commun. | volume = 260 | issue = 1 | pages = 273–79 |date=June 1999 | pmid = 10381378 | doi = 10.1006/bbrc.1999.0897 | url = | issn = }}
2. ^1 {{cite web | title = Entrez Gene: Sirtuin 4 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23409 | accessdate = }}
3. ^1 {{cite journal | vauthors = Tanny JC, Dowd GJ, Huang J, Hilz H, Moazed D | title = An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing | journal = Cell | volume = 99 | issue = 7 | pages = 735–45 |date=December 1999 | pmid = 10619427 | doi = 10.1016/S0092-8674(00)81671-2| url = http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(00)81671-2 | issn = }}
4. ^{{cite journal | vauthors = Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L | title = SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells | journal = Cell | volume = 126 | issue = 5 | pages = 941–54 |date=September 2006 | pmid = 16959573 | doi = 10.1016/j.cell.2006.06.057 | url = | issn = }}
5. ^{{cite journal | vauthors = Nasrin N, Wu X, Fortier E, Feng Y, Bare' OC, Chen S, Ren X, Wu Z, Streeper RS, Bordone L | title = SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. In primary myotubes and hepatocytes, knockdown of SIRT4 results in increased Fatty Acid Oxidation, cellular respiration, and pAMPK levels. SIRT4 inhibition increases fat oxidative capacity in liver and mitochondrial function in muscle, which might provide therapeutic benefits for diseases associated with ectopic lipid storage such as type 2 diabetes. | journal = J. Biol. Chem. | volume = 285 | issue = 42 | pages = 31995–32002 |date=October 2010 | pmid = 20685656 | pmc = 2952200 | doi = 10.1074/jbc.M110.124164 | url = | issn = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Yamamoto H, Schoonjans K, Auwerx J |title=Sirtuin functions in health and disease. |journal=Mol. Endocrinol. |volume=21 |issue= 8 |pages= 1745–55 |year= 2007 |pmid= 17456799 |doi= 10.1210/me.2007-0079 }}
  • {{cite journal |vauthors=Michishita E, Park JY, Burneskis JM, etal |title=Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins |journal=Mol. Biol. Cell |volume=16 |issue= 10 |pages= 4623–35 |year= 2005 |pmid= 16079181 |doi= 10.1091/mbc.E05-01-0033 |pmc=1237069 }}
  • {{cite journal |vauthors=Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, etal |title=Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study|journal=Eur. J. Hum. Genet. |volume=17 |issue= 8 |pages= 1056–62 |year= 2009 |pmid= 19209188 |pmc=2986549 |doi= 10.1038/ejhg.2009.4 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–27 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 }}
  • {{cite journal |authorlink1=Nita Ahuja |vauthors=Ahuja N, Schwer B, Carobbio S, etal |title=Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. |journal=J. Biol. Chem. |volume=282 |issue= 46 |pages= 33583–92 |year= 2007 |pmid= 17715127 |doi= 10.1074/jbc.M705488200 }}
  • {{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1998 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The }}
  • {{cite journal |author=Frye RA |title=Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 2 |pages= 793–98 |year= 2000 |pmid= 10873683 |doi= 10.1006/bbrc.2000.3000 }}
  • {{cite journal |vauthors=Irobi J, Van Impe K, Seeman P, etal |title=Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. |journal=Nat. Genet. |volume=36 |issue= 6 |pages= 597–601 |year= 2004 |pmid= 15122253 |doi= 10.1038/ng1328 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M }}
  • {{cite journal |vauthors=Scherer SE, Muzny DM, Buhay CJ, etal |title=The finished DNA sequence of human chromosome 12 |journal=Nature |volume=440 |issue= 7082 |pages= 346–51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 |bibcode=2006Natur.440..346S }}
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