“SIX1”的意思、由来-开放百科全书

Function

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein–protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM]^[3]

References

1. ^{{cite journal | vauthors = Boucher CA, Carey N, Edwards YH, Siciliano MJ, Johnson KJ | title = Cloning of the human SIX1 gene and its assignment to chromosome 14 | journal = Genomics | volume = 33 | issue = 1 | pages = 140–2 | date = April 1996 | pmid = 8617500 | pmc = | doi = 10.1006/geno.1996.0172 }}
2. ^{{cite journal | vauthors = Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F | title = SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 21 | pages = 8090–5 | date = May 2004 | pmid = 15141091 | pmc = 419562 | doi = 10.1073/pnas.0308475101 }}
3. ^¹{{cite web | title = Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6495| accessdate = }}
4. ^{{cite journal | vauthors = Buller C, Xu X, Marquis V, Schwanke R, Xu PX | title = Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome | journal = Human Molecular Genetics | volume = 10 | issue = 24 | pages = 2775–81 | date = November 2001 | pmid = 11734542 | doi = 10.1093/hmg/10.24.2775 }}
5. ^{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

Further reading

{{cite journal | vauthors = Oliver G, Wehr R, Jenkins NA, Copeland NG, Cheyette BN, Hartenstein V, Zipursky SL, Gruss P | title = Homeobox genes and connective tissue patterning | journal = Development | volume = 121 | issue = 3 | pages = 693–705 | date = March 1995 | pmid = 7720577 | doi = }}

Adrados, I., Larrasa-Alonso, J., Galarreta, A., López-Antona, I., Menéndez, C., Abad, M., ... & Palmero, I. (2015). The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes. Oncogene. {{doi|10.1038/onc.2015.408}}

{{cite journal | vauthors = Ford HL, Kabingu EN, Bump EA, Mutter GL, Pardee AB | title = Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 21 | pages = 12608–13 | date = October 1998 | pmid = 9770533 | pmc = 22878 | doi = 10.1073/pnas.95.21.12608 }}

{{cite journal | vauthors = Salam AA, Häfner FM, Linder TE, Spillmann T, Schinzel AA, Leal SM | title = A novel locus (DFNA23) for prelingual autosomal dominant nonsyndromic hearing loss maps to 14q21-q22 in a Swiss German kindred | journal = American Journal of Human Genetics | volume = 66 | issue = 6 | pages = 1984–8 | date = June 2000 | pmid = 10777717 | pmc = 1378045 | doi = 10.1086/302931 }}

{{cite journal | vauthors = Ford HL, Landesman-Bollag E, Dacwag CS, Stukenberg PT, Pardee AB, Seldin DC | title = Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein | journal = The Journal of Biological Chemistry | volume = 275 | issue = 29 | pages = 22245–54 | date = July 2000 | pmid = 10801845 | doi = 10.1074/jbc.M002446200 }}

{{cite journal | vauthors = Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR | title = The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 41 | pages = 32129–34 | date = October 2000 | pmid = 10906137 | doi = 10.1074/jbc.M004577200 }}

{{cite journal | vauthors = Buller C, Xu X, Marquis V, Schwanke R, Xu PX | title = Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome | journal = Human Molecular Genetics | volume = 10 | issue = 24 | pages = 2775–81 | date = November 2001 | pmid = 11734542 | doi = 10.1093/hmg/10.24.2775 }}

{{cite journal | vauthors = Li CM, Guo M, Borczuk A, Powell CA, Wei M, Thaker HM, Friedman R, Klein U, Tycko B | title = Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition | journal = The American Journal of Pathology | volume = 160 | issue = 6 | pages = 2181–90 | date = June 2002 | pmid = 12057921 | pmc = 1850829 | doi = 10.1016/S0002-9440(10)61166-2 }}

{{cite journal | vauthors = Ikeda K, Watanabe Y, Ohto H, Kawakami K | title = Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6759–66 | date = October 2002 | pmid = 12215533 | pmc = 134036 | doi = 10.1128/MCB.22.19.6759-6766.2002 }}

{{cite journal | vauthors = López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P | title = Six3 and Six6 activity is modulated by members of the groucho family | journal = Development | volume = 130 | issue = 1 | pages = 185–95 | date = January 2003 | pmid = 12441302 | doi = 10.1242/dev.00185 }}

{{cite journal | vauthors = Ruf RG, Berkman J, Wolf MT, Nurnberg P, Gattas M, Ruf EM, Hyland V, Kromberg J, Glass I, Macmillan J, Otto E, Nurnberg G, Lucke B, Hennies HC, Hildebrandt F | title = A gene locus for branchio-otic syndrome maps to chromosome 14q21.3-q24.3 | journal = Journal of Medical Genetics | volume = 40 | issue = 7 | pages = 515–9 | date = July 2003 | pmid = 12843324 | pmc = 1735534 | doi = 10.1136/jmg.40.7.515 }}

{{cite journal | vauthors = Zheng W, Huang L, Wei ZB, Silvius D, Tang B, Xu PX | title = The role of Six1 in mammalian auditory system development | journal = Development | volume = 130 | issue = 17 | pages = 3989–4000 | date = September 2003 | pmid = 12874121 | doi = 10.1242/dev.00628 | pmc = 3873880 }}

{{cite journal | vauthors = Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG | title = Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis | journal = Nature | volume = 426 | issue = 6964 | pages = 247–54 | date = November 2003 | pmid = 14628042 | doi = 10.1038/nature02083 }}

{{cite journal | vauthors = Coletta RD, Christensen K, Reichenberger KJ, Lamb J, Micomonaco D, Huang L, Wolf DM, Müller-Tidow C, Golub TR, Kawakami K, Ford HL | title = The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 17 | pages = 6478–83 | date = April 2004 | pmid = 15123840 | pmc = 404070 | doi = 10.1073/pnas.0401139101 }}

{{cite journal | vauthors = Grifone R, Laclef C, Spitz F, Lopez S, Demignon J, Guidotti JE, Kawakami K, Xu PX, Kelly R, Petrof BJ, Daegelen D, Concordet JP, Maire P | title = Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype | journal = Molecular and Cellular Biology | volume = 24 | issue = 14 | pages = 6253–67 | date = July 2004 | pmid = 15226428 | pmc = 434262 | doi = 10.1128/MCB.24.14.6253-6267.2004 }}

{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

{{cite journal | vauthors = Ito T, Noguchi Y, Yashima T, Kitamura K | title = SIX1 mutation associated with enlargement of the vestibular aqueduct in a patient with branchio-oto syndrome | journal = The Laryngoscope | volume = 116 | issue = 5 | pages = 796–9 | date = May 2006 | pmid = 16652090 | doi = 10.1097/01.mlg.0000209096.40400.96 }}

1 : Transcription factors

Function

Interactions

References

Further reading