| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.[1][2]This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.[2] The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection [3] and by the SKAP1 deficient mouse.[4] Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells.[5][6] Interactions SKAP1 has been shown to interact with FYN,[1][7][8] PTPRC[9] and FYB.[8][10] References 1. ^1 {{cite journal | vauthors = Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B | title = Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes | journal = The Journal of Biological Chemistry | volume = 272 | issue = 26 | pages = 16077–80 | date = June 1997 | pmid = 9195899 | pmc = | doi = 10.1074/jbc.272.26.16077 }}
2. ^1 {{cite web | title = Entrez Gene: SKAP1 src kinase associated phosphoprotein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8631| accessdate = }}
3. ^{{cite journal | vauthors = Wang H, Moon EY, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE | title = SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates | journal = Nature Immunology | volume = 4 | issue = 4 | pages = 366–74 | date = April 2003 | pmid = 12652296 | doi = 10.1038/ni913 }}
4. ^Wang H, Liu H, Lu Y, Lovatt M, Wei, B, Rudd CE Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion, Mol. Cell. Biol. 2007 27, 6863-75.
5. ^* {{cite journal | vauthors = Kosco KA, Cerignoli F, Williams S, Abraham RT, Mustelin T | title = SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1 | journal = Molecular Immunology | volume = 45 | issue = 2 | pages = 510–22 | date = January 2008 | pmid = 17658605 | doi = 10.1016/j.molimm.2007.05.024 }}
6. ^Schneider H., Wang H., Raab M., Valk E., Smith X. , Lovatt M., Wu Z., Strebhardt K, Rudd, CE. Adaptor SKAP55 binds RasGRP1 and negatively regulates p21ras and the ERK pathway in T-cells. (2008) PLoS ONE. 3, 1718.
7. ^{{cite journal | vauthors = Wu L, Yu Z, Shen SH | title = SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40420–7 | date = October 2002 | pmid = 12171928 | doi = 10.1074/jbc.M206023200 }}
8. ^1 {{cite journal | vauthors = Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA | title = Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 40 | pages = 25789–95 | date = October 1998 | pmid = 9748251 | doi = 10.1074/jbc.273.40.25789 }}
9. ^{{cite journal | vauthors = Wu L, Fu J, Shen SH | title = SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2673–86 | date = April 2002 | pmid = 11909961 | pmc = 133720 | doi = 10.1128/MCB.22.8.2673-2686.2002 }}
10. ^{{cite journal | vauthors = Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE | title = FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8779–84 | date = July 1998 | pmid = 9671755 | pmc = 21153 | doi = 10.1073/pnas.95.15.8779 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Schraven B, Marie-Cardine A, Koretzky G | title = Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling | journal = Immunology Letters | volume = 57 | issue = 1-3 | pages = 165–9 | date = June 1997 | pmid = 9232446 | doi = 10.1016/S0165-2478(97)00053-9 }}
- {{cite journal | vauthors = Clements JL, Boerth NJ, Lee JR, Koretzky GA | title = Integration of T cell receptor-dependent signaling pathways by adapter proteins | journal = Annual Review of Immunology | volume = 17 | issue = | pages = 89–108 | year = 1999 | pmid = 10358754 | doi = 10.1146/annurev.immunol.17.1.89 }}
- {{cite journal | vauthors = Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE | title = FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8779–84 | date = July 1998 | pmid = 9671755 | pmc = 21153 | doi = 10.1073/pnas.95.15.8779 }}
- {{cite journal | vauthors = Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA | title = Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 40 | pages = 25789–95 | date = October 1998 | pmid = 9748251 | doi = 10.1074/jbc.273.40.25789 }}
- {{cite journal | vauthors = Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T | title = RA70 is a src kinase-associated protein expressed ubiquitously | journal = Biochemical and Biophysical Research Communications | volume = 252 | issue = 3 | pages = 738–42 | date = November 1998 | pmid = 9837776 | doi = 10.1006/bbrc.1998.9637 }}
- {{cite journal | vauthors = Kang H, Freund C, Duke-Cohan JS, Musacchio A, Wagner G, Rudd CE | title = SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55 | journal = The EMBO Journal | volume = 19 | issue = 12 | pages = 2889–99 | date = June 2000 | pmid = 10856234 | pmc = 203341 | doi = 10.1093/emboj/19.12.2889 }}
- {{cite journal | vauthors = Wu L, Fu J, Shen SH | title = SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2673–86 | date = April 2002 | pmid = 11909961 | pmc = 133720 | doi = 10.1128/MCB.22.8.2673-2686.2002 }}
- {{cite journal | vauthors = Wu L, Yu Z, Shen SH | title = SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40420–7 | date = October 2002 | pmid = 12171928 | doi = 10.1074/jbc.M206023200 }}
- {{cite journal | vauthors = Huang Y, Norton DD, Precht P, Martindale JL, Burkhardt JK, Wange RL | title = Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells | journal = The Journal of Biological Chemistry | volume = 280 | issue = 25 | pages = 23576–83 | date = June 2005 | pmid = 15849195 | doi = 10.1074/jbc.M413201200 }}
- {{cite journal | vauthors = Jo EK, Wang H, Rudd CE | title = An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R | journal = The Journal of Experimental Medicine | volume = 201 | issue = 11 | pages = 1733–9 | date = June 2005 | pmid = 15939789 | pmc = 2213273 | doi = 10.1084/jem.20042577 }}
- {{cite journal | vauthors = Duke-Cohan JS, Kang H, Liu H, Rudd CE | title = Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein | journal = The Journal of Biological Chemistry | volume = 281 | issue = 19 | pages = 13743–50 | date = May 2006 | pmid = 16461356 | doi = 10.1074/jbc.M508774200 }}
- {{cite journal | vauthors = Kliche S, Breitling D, Togni M, Pusch R, Heuer K, Wang X, Freund C, Kasirer-Friede A, Menasche G, Koretzky GA, Schraven B | title = The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1 | journal = Molecular and Cellular Biology | volume = 26 | issue = 19 | pages = 7130–44 | date = October 2006 | pmid = 16980616 | pmc = 1592884 | doi = 10.1128/MCB.00331-06 }}
{{refend}}{{PDB Gallery|geneid=8631}}{{gene-17-stub}} |