“(Skp1-protein)-hydroxyproline N-acetylglucosaminyltransferase”的意思、由来-开放百科全书

词条

(Skp1-protein)-hydroxyproline N-acetylglucosaminyltransferase

释义

References

{{enzyme
| Name = (Skp1-protein)-hydroxyproline N-acetylglucosaminyltransferase
| EC_number = 2.4.1.229
| CAS_number =
| IUBMB_EC_number = 2/4/1/229
| GO_code =
| image =
| width =
| caption =
}}

In enzymology, a [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase ({{EC number|2.4.1.229}}) is an enzyme that catalyzes the chemical reaction

UDP-N-acetylglucosamine + [Skp₁-protein]-hydroxyproline UDP + [Skp₁-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline

Thus, the two substrates of this enzyme are UDP-N-acetylglucosamine and Skp1-protein-hydroxyproline, whereas its two products are UDP and Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:[Skp1-protein]-hydroxyproline N-acetyl-D-glucosaminyl-transferase. Other names in common use include Skp1-HyPro GlcNAc-transferase, UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide, GlcNAc-transferase, UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase, and UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase.

References

{{cite journal | author = CM | date = 2002 | title = Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of dictyostelium | journal = J. Biol. Chem. | volume = 277 | pages = 46328–37 | pmid = 12244115 | doi = 10.1074/jbc.M208024200 | last2 = Morris | first2 = HR | last3 = Panico | first3 = M | last4 = Paxton | first4 = T | last5 = Dell | first5 = A | last6 = Kaplan | first6 = L | last7 = West | first7 = CM | issue = 48 }}
{{cite journal |vauthors=Teng-Umnuay P, van der Wel H, West CM | date = 1999 | title = Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the cytoplasm of Dictyostelium | journal = J. Biol. Chem. | volume = 274 | pages = 36392–402 | pmid = 10593934 | doi = 10.1074/jbc.274.51.36392 | issue = 51 }}
{{cite journal |vauthors=West CM, van der Wel H, Gaucher EA | date = 2002 | title = Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins | journal = Glycobiology | volume = 12 | pages = 17R–27R | pmid = 11886837 | doi = 10.1093/glycob/12.2.17R | issue = 2 }}

{{Glycosyltransferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Skp1-Protein-Hydroxyproline N-Acetylglucosaminyltransferase}}{{2.4-enzyme-stub}}

2 : EC 2.4.1|Enzymes of unknown structure

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