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词条 SLAMF7
释义

  1. References

  2. Further reading

{{Infobox_gene}}SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene.[1][2][3]

The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.[4]

Elotuzumab is an antibody that targets this protein.

References

1. ^{{cite journal | vauthors = Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD | title = A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion | journal = The Biochemical Journal | volume = 361 | issue = Pt 3 | pages = 431–6 | date = Feb 2002 | pmid = 11802771 | pmc = 1222324 | doi = 10.1042/0264-6021:3610431 }}
2. ^{{cite journal | vauthors = Boles KS, Mathew PA | title = Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily | journal = Immunogenetics | volume = 52 | issue = 3-4 | pages = 302–7 | date = Feb 2001 | pmid = 11220635 | pmc = | doi = 10.1007/s002510000274 }}
3. ^{{cite web | title = Entrez Gene: SLAMF7 SLAM family member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57823| accessdate = }}
4. ^{{cite journal | vauthors = Frigyesi I, Adolfsson J, Ali M, Christophersen MK, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B | title = Robust isolation of malignant plasma cells in multiple myeloma | journal = Blood | volume = 123 | issue = 9 | pages = 1336–40 | date = Feb 2014 | pmid = 24385542 | doi = 10.1182/blood-2013-09-529800 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Claus M, Meinke S, Bhat R, Watzl C | title = Regulation of NK cell activity by 2B4, NTB-A and CRACC | journal = Frontiers in Bioscience | volume = 13 | issue = 13 | pages = 956–65 | year = 2007 | pmid = 17981603 | doi = 10.2741/2735 }}
  • {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
  • {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
  • {{cite journal | vauthors = Bouchon A, Cella M, Grierson HL, Cohen JI, Colonna M | title = Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family | journal = Journal of Immunology | volume = 167 | issue = 10 | pages = 5517–21 | date = Nov 2001 | pmid = 11698418 | doi = 10.4049/jimmunol.167.10.5517 }}
  • {{cite journal | vauthors = Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P | title = Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors | journal = Immunogenetics | volume = 54 | issue = 6 | pages = 394–402 | date = Sep 2002 | pmid = 12242590 | doi = 10.1007/s00251-002-0483-3 }}
  • {{cite journal | vauthors = Del Valle JM, Engel P, Martín M | title = The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) | journal = The Journal of Biological Chemistry | volume = 278 | issue = 19 | pages = 17430–7 | date = May 2003 | pmid = 12621057 | doi = 10.1074/jbc.M301569200 }}
  • {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = Oct 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
  • {{cite journal | vauthors = Lee JK, Boles KS, Mathew PA | title = Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs | journal = European Journal of Immunology | volume = 34 | issue = 10 | pages = 2791–9 | date = Oct 2004 | pmid = 15368295 | doi = 10.1002/eji.200424917 }}
  • {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
  • {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
  • {{cite journal | vauthors = Stark S, Watzl C | title = 2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells | journal = International Immunology | volume = 18 | issue = 2 | pages = 241–7 | date = Feb 2006 | pmid = 16410313 | doi = 10.1093/intimm/dxh358 }}
  • {{cite journal | vauthors = Lee JK, Mathew SO, Vaidya SV, Kumaresan PR, Mathew PA | title = CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes | journal = Journal of Immunology | volume = 179 | issue = 7 | pages = 4672–8 | date = Oct 2007 | pmid = 17878365 | doi = 10.4049/jimmunol.179.7.4672 }}
  • {{cite journal | vauthors = Malaer JD, Mathew PA | title = CS1 (SLAMF7, CD319) is an effective immunotherapeutic target for multiple myeloma | journal = American Journal of Cancer Research | volume = 7 | issue = 8 | pages = 1637–41 | date = Aug 2017 | pmid = 28861320 }}
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