| 释义 |
- Function
- See also
- References
- Further reading
{{Infobox_gene}}Solute carrier family 30 (zinc transporter), member 1 is a protein which in humans is encoded by the SLC30A1 gene.[1][2]FunctionSLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[3] See alsoReferences1. ^{{cite journal | vauthors = Palmiter RD, Findley SD | title = Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc | journal = The EMBO Journal | volume = 14 | issue = 4 | pages = 639–49 |date=February 1995 | pmid = 7882967 | pmc = 398127 | doi = | url = | issn = }}
2. ^{{cite journal | vauthors = Seve M, Chimienti F, Devergnas S, Favier A | title = In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression | journal = BMC Genomics | volume = 5 | pages = 32 |date=May 2004 | pmid = 15154973 | pmc = 428573 | doi = 10.1186/1471-2164-5-32 | url = | issn = | issue=1}}
3. ^{{cite journal | vauthors = Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I | title = A role for ZnT-1 in regulating cellular cation influx | journal = Biochemical and Biophysical Research Communications | volume = 323 | issue = 4 | pages = 1145–50 |date=October 2004 | pmid = 15451416 | doi = 10.1016/j.bbrc.2004.08.211 | url = | issn = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Guey LT, GarcÃa-Closas M, Murta-Nascimento C, etal |title=Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes. |journal=Eur. Urol. |volume= 57|issue= 2|pages= HASH(0x24ec9d0) |year= 2009 |pmid= 19692168 |doi= 10.1016/j.eururo.2009.08.001 |pmc=3220186}}
- {{cite journal |vauthors=Zhang LH, Wang X, Stoltenberg M, etal |title=Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. |journal=Brain Res. Bull. |volume=77 |issue= 1 |pages= 55–60 |year= 2008 |pmid= 18639746 |doi= 10.1016/j.brainresbull.2008.03.014 }}
- {{cite journal |vauthors=Lovell MA, Smith JL, Xiong S, Markesbery WR |title=Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease. |journal=Neurotoxicity research |volume=7 |issue= 4 |pages= 265–71 |year= 2005 |pmid= 16179263 |doi=10.1007/BF03033884 }}
- {{cite journal |vauthors=Zhang LY, Wang XL, Sun DX, etal |title=Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. |journal=Mol. Biol. Rep. |volume=35 |issue= 4 |pages= 595–600 |year= 2008 |pmid= 17786585 |doi= 10.1007/s11033-007-9129-8 }}
- {{cite journal |vauthors=Iguchi K, Otsuka T, Usui S, etal |title=Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. |journal=J. Androl. |volume=25 |issue= 1 |pages= 154–61 |year= 2004|pmid= 14662799 |doi= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 }}
- {{cite journal |vauthors=Lazarczyk M, Pons C, Mendoza JA, etal |title=Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. |journal=J. Exp. Med. |volume=205 |issue= 1 |pages= 35–42 |year= 2008 |pmid= 18158319 |doi= 10.1084/jem.20071311 |pmc=2234378 }}
- {{cite journal |vauthors=Overbeck S, Uciechowski P, Ackland ML, etal |title=Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. |journal=J. Leukoc. Biol. |volume=83 |issue= 2 |pages= 368–80 |year= 2008 |pmid= 17971500 |doi= 10.1189/jlb.0307148 }}
- {{cite journal |vauthors=Hosgood HD, Menashe I, He X, etal |title=PTEN identified as important risk factor of chronic obstructive pulmonary disease. |journal=Respiratory medicine |volume= 103|issue= 12|pages= HASH(0x15616e0) |year= 2009 |pmid= 19625176 |doi= 10.1016/j.rmed.2009.06.016 |pmc=2783799 }}
- {{cite journal |vauthors=Hosgood HD, Menashe I, Shen M, etal |title=Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. |journal=Carcinogenesis |volume=29 |issue= 10 |pages= 1938–43 |year= 2008 |pmid= 18676680 |doi= 10.1093/carcin/bgn178 |pmc=2722857 }}
- {{cite journal |vauthors=Etzion Y, Ganiel A, Beharier O, etal |title=Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study. |journal=J. Cardiovasc. Electrophysiol. |volume=19 |issue= 2 |pages= 157–64 |year= 2008 |pmid= 17971132 |doi= 10.1111/j.1540-8167.2007.01008.x }}
- {{cite journal |vauthors=Barbe L, Lundberg E, Oksvold P, etal |title=Toward a confocal subcellular atlas of the human proteome. |journal=Mol. Cell. Proteomics |volume=7 |issue= 3 |pages= 499–508 |year= 2008 |pmid= 18029348 |doi= 10.1074/mcp.M700325-MCP200 }}
{{refend}}{{Membrane transport proteins}}{{Metal metabolism}}{{gene-11-stub}} |