| 释义 |
- See also
- References
- Further reading
{{Infobox_gene}}Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.[3]
}}See alsoReferences1. ^{{cite journal | vauthors = Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H | title = Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters | journal = J Biol Chem | volume = 277 | issue = 25 | pages = 22966–73 |date=Jun 2002 | pmid = 11959859 | pmc = | doi = 10.1074/jbc.M200374200 }}
2. ^{{cite journal | vauthors = Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B | title = Identification and characterization of a lysosomal transporter for small neutral amino acids | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 13 | pages = 7206–11 |date=Jun 2001 | pmid = 11390972 | pmc = 34647 | doi = 10.1073/pnas.121183498 }}
3. ^1 {{cite web | title = Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=206358| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
- {{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
- {{cite journal |vauthors=Chen Z, Fei YJ, Anderson CM, etal |title=Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2 |journal=J. Physiol. |volume=546 |issue= Pt 2 |pages= 349–61 |year= 2003 |pmid= 12527723 |doi=10.1113/jphysiol.2002.026500 | pmc=2342508 }}
- {{cite journal |vauthors=Wreden CC, Johnson J, Tran C, etal |title=The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1265–75 |year= 2003 |pmid= 12598615 |doi= }}
- {{cite journal | vauthors=Boll M, Foltz M, Rubio-Aliaga I, Daniel H |title=A cluster of proton/amino acid transporter genes in the human and mouse genomes |journal=Genomics |volume=82 |issue= 1 |pages= 47–56 |year= 2004 |pmid= 12809675 |doi=10.1016/S0888-7543(03)00099-5 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal | vauthors=Bermingham JR, Pennington J |title=Organization and expression of the SLC36 cluster of amino acid transporter genes |journal=Mamm. Genome |volume=15 |issue= 2 |pages= 114–25 |year= 2004 |pmid= 15058382 |doi=10.1007/s00335-003-2319-3 }}
- {{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
- {{cite journal |vauthors=Anderson CM, Grenade DS, Boll M, etal |title=H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat |journal=Gastroenterology |volume=127 |issue= 5 |pages= 1410–22 |year= 2004 |pmid= 15521011 |doi=10.1053/j.gastro.2004.08.017 }}
- {{cite journal | vauthors=Anderson CM, Thwaites DT |title=Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1) |journal=J. Cell. Physiol. |volume=204 |issue= 2 |pages= 604–13 |year= 2005 |pmid= 15754324 |doi= 10.1002/jcp.20337 }}
- {{cite journal |vauthors=Abbot EL, Grenade DS, Kennedy DJ, etal |title=Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1 |journal=Br. J. Pharmacol. |volume=147 |issue= 3 |pages= 298–306 |year= 2006 |pmid= 16331283 |doi= 10.1038/sj.bjp.0706557 | pmc=1751303 }}
- {{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
- {{cite journal |vauthors=Kuan YH, Gruebl T, Soba P, etal |title=PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2 |journal=J. Biol. Chem. |volume=281 |issue= 52 |pages= 40114–23 |year= 2007 |pmid= 17050537 |doi= 10.1074/jbc.M605407200 }}
{{refend}}{{NLM content}}{{Membrane transport proteins}}{{membrane-protein-stub}} 1 : Solute carrier family |