| 释义 |
- Regulation
- References
- Further reading
{{Infobox_gene}}Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene.[1][2][3]SLC45A3 is expressed in a prostate-specific manner by normal tissues and at a significantly lower level in prostate tumor cell lines. Treatment prostate cancer cell lines with androgens upregulates the expression of SLC45A3.[3] RegulationThere is evidence that the expression of SLC45A3 is regulated by the microRNA mir-126*.[4] References1. ^{{cite web | title = Entrez Gene: solute carrier family 45| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85414| accessdate = }}
2. ^{{cite journal |author1=Walker MG |author2=Volkmuth W |author3=Sprinzak E |author4=Hodgson D |author5=Klingler T | title = Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes | journal = Genome Res. | volume = 9 | issue = 12 | pages = 1198–203 |date=December 1999 | pmid = 10613842 | pmc = 310991 | doi = 10.1101/gr.9.12.1198| url = | issn = }}
3. ^1 {{cite journal |author1=Xu J |author2=Kalos M |author3=Stolk JA |author4=Zasloff EJ |author5=Zhang X |author6=Houghton RL |author7=Filho AM |author8=Nolasco M |author9=Badaró R |author10=Reed SG | title = Identification and characterization of prostein, a novel prostate-specific protein | journal = Cancer Res. | volume = 61 | issue = 4 | pages = 1563–8 |date=February 2001 | pmid = 11245466 | doi = | url = | issn = }}
4. ^{{cite journal |author1=Musiyenko A |author2=Bitko V |author3=Barik S |title=Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. |journal=J Mol Med |volume=86 |issue=3 |pages=313–22 |year=2008 |pmid=18193184 |doi=10.1007/s00109-007-0296-9 |pmc=3263384}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Pflueger D, Rickman DS, Sboner A, etal |title=N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer. |journal=Neoplasia |volume=11 |issue= 8 |pages= 804–11 |year= 2009 |pmid= 19649210 |doi=10.1593/neo.09572 |pmc=2713587}}
- {{cite journal |vauthors=Helgeson BE, Tomlins SA, Shah N, etal |title=Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer. |journal=Cancer Res. |volume=68 |issue= 1 |pages= 73–80 |year= 2008 |pmid= 18172298 |doi= 10.1158/0008-5472.CAN-07-5352 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
- {{cite journal |vauthors=Esgueva R, Perner S, J LaFargue C, etal |title=Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. |journal=Mod. Pathol. |volume=23 |issue= 4 |pages= 539–46 |year= 2010 |pmid= 20118910 |doi= 10.1038/modpathol.2009.193 |pmc=2848699}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129}}
- {{cite journal |author1=Friedman RS |author2=Spies AG |author3=Kalos M |title=Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate. |journal=Eur. J. Immunol. |volume=34 |issue= 4 |pages= 1091–101 |year= 2004 |pmid= 15048720 |doi= 10.1002/eji.200324768 }}
- {{cite journal |vauthors=Maher CA, Kumar-Sinha C, Cao X, etal |title=Transcriptome sequencing to detect gene fusions in cancer. |journal=Nature |volume=458 |issue= 7234 |pages= 97–101 |year= 2009 |pmid= 19136943 |doi= 10.1038/nature07638 |pmc=2725402}}
- {{cite journal |author1=Musiyenko A |author2=Bitko V |author3=Barik S |title=Ectopic expression of miR-126, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. |journal=J. Mol. Med. |volume=86 |issue= 3 |pages= 313–22 |year= 2008 |pmid= 18193184 |doi= 10.1007/s00109-007-0296-9 |pmc=3263384}}
- {{cite journal |author1=Kiessling A |author2=Stevanovic S |author3=Füssel S |author4=Weigle B |author5=Rieger MA |author6=Temme A |author7=Rieber EP |author8=Schmitz M | title = Identification of an HLA-A0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein | journal = Br. J. Cancer | volume = 90 | issue = 5 | pages = 1034–40 |date=March 2004 | pmid = 14997204 | pmc = 2410218 | doi = 10.1038/sj.bjc.6601642 | url = | issn = }}
- {{cite journal |vauthors=Satake W, Nakabayashi Y, Mizuta I, etal |title=Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. |journal=Nat. Genet. |volume=41 |issue= 12 |pages= 1303–7 |year= 2009 |pmid= 19915576 |doi= 10.1038/ng.485 }}
- {{cite journal |vauthors=Kalos M, Askaa J, Hylander BL, etal |title=Prostein expression is highly restricted to normal and malignant prostate tissues. |journal=Prostate |volume=60 |issue= 3 |pages= 246–56 |year= 2004 |pmid= 15176054 |doi= 10.1002/pros.20043 }}
- {{cite journal |author1=Sheridan T |author2=Herawi M |author3=Epstein JI |author4=Illei PB |title=The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate. |journal=Am. J. Surg. Pathol. |volume=31 |issue= 9 |pages= 1351–5 |year= 2007 |pmid= 17721190 |doi= 10.1097/PAS.0b013e3180536678 }}
{{refend}}{{Membrane transport proteins}}{{gene-1-stub}} 1 : Prostate cancer |