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词条 SLC4A2
释义

  1. See also

  2. References

  3. Further reading

{{Infobox_gene}}

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.[1][2] AE2 is functionally similar to the Band 3 Cl−/HCO3− exchange protein.

Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3− transport in the gastrointestinal tract.[3] AE2 is required for spermiogenesis in mice.[4] AE2 is required for normal osteoclast function.[5][6] The activity of AE2 is sensitive to pH.[7]

AE3 has been suggested as a target for prevention of diabetic vasculopathy.[8]

See also

  • Solute carrier family

References

1. ^{{cite journal | author = Tanner MJ | title = Molecular and cellular biology of the erythrocyte anion exchanger (AE1) | journal = Semin Hematol | volume = 30 | issue = 1 | pages = 34–57 |date=Mar 1993 | pmid = 8434259}}
2. ^{{cite web | title = Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6522| accessdate = }}
3. ^{{cite journal | vauthors = Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE | title = AE2 Cl−/HCO3− exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon | journal = Am. J. Physiol. Gastrointest. Liver Physiol. | volume = 298 | issue = 4 | pages = G493–503 |date=April 2010 | pmid = 20110461 | pmc = 2853300 | doi = 10.1152/ajpgi.00178.2009 }}
4. ^{{cite journal | vauthors = Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP | title = Anion exchanger 2 is essential for spermiogenesis in mice | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 26 | pages = 15847–52 |date=December 2003 | pmid = 14673081 | pmc = 307656 | doi = 10.1073/pnas.2536127100 }}
5. ^{{cite journal | vauthors = Wu J, Glimcher LH, Aliprantis AO | title = HCO3−/Cl− anion exchanger SLC4A2 is required for proper osteoclast differentiation and function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 44 | pages = 16934–9 |date=November 2008 | pmid = 18971331 | pmc = 2579356 | doi = 10.1073/pnas.0808763105 | url = }}
6. ^{{cite journal | vauthors = Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O | title = Targeted disruption of the Cl−/HCO3− exchanger Ae2 results in osteopetrosis in mice | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 106 | issue = 5 | pages = 1638–41 |date=February 2009 | pmid = 19164575 | pmc = 2635809 | doi = 10.1073/pnas.0811682106 }}
7. ^{{cite journal | vauthors = Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL | title = Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH | journal = J. Biol. Chem. | volume = 284 | issue = 10 | pages = 6126–39 |date=March 2009 | pmid = 19103596 | pmc = 2649077 | doi = 10.1074/jbc.M802051200 }}
8. ^{{cite journal | vauthors = Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M | title = Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway | journal = Apoptosis | volume = 15 | issue = 6 | pages = 693–704 |date=June 2010 | pmid = 20180022 | doi = 10.1007/s10495-010-0477-9 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Gehrig H, Müller W, Appelhans H |title=Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney. |journal=Biochim. Biophys. Acta |volume=1130 |issue= 3 |pages= 326–8 |year= 1992 |pmid= 1562608 |doi=10.1016/0167-4781(92)90446-7}}
  • {{cite journal | vauthors=Korsgren C, Cohen CM |title=Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3. |journal=J. Biol. Chem. |volume=263 |issue= 21 |pages= 10212–8 |year= 1988 |pmid= 2968981 }}
  • {{cite journal |vauthors=Demuth DR, Showe LC, Ballantine M, etal |title=Cloning and structural characterization of a human non-erythroid band 3-like protein. |journal=EMBO J. |volume=5 |issue= 6 |pages= 1205–14 |year= 1986 |pmid= 3015590 | pmc=1166929 }}
  • {{cite journal |vauthors=Palumbo AP, Isobe M, Huebner K, etal |title=Chromosomal localization of a human band 3-like gene to region 7q35----7q36. |journal=Am. J. Hum. Genet. |volume=39 |issue= 3 |pages= 307–16 |year= 1986 |pmid= 3020980 | pmc=1683956 }}
  • {{cite journal | vauthors=Rybicki AC, Musto S, Schwartz RS |title=Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2. | series=309 |journal=Biochem. J. |volume=( Pt 2) |issue= |pages= 677–81 |year= 1995 |pmid= 7626035 | pmc=1135783 }}
  • {{cite journal | vauthors=Havenga MJ, Bosman GJ, Appelhans H, De Grip WJ |title=Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0. |journal=Brain Res. Mol. Brain Res. |volume=25 |issue= 1–2 |pages= 97–104 |year= 1995 |pmid= 7984058 |doi=10.1016/0169-328X(94)90283-6 }}
  • {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
  • {{cite journal | vauthors=Medina JF, Acín A, Prieto J |title=Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene. |journal=Genomics |volume=39 |issue= 1 |pages= 74–85 |year= 1997 |pmid= 9027488 |doi=10.1006/geno.1996.4467 }}
  • {{cite journal | vauthors=García C, Montuenga LM, Medina JF, Prieto J |title=In situ detection of AE2 anion-exchanger mRNA in the human liver. |journal=Cell Tissue Res. |volume=291 |issue= 3 |pages= 481–8 |year= 1998 |pmid= 9477304 |doi=10.1007/s004410051017 }}
  • {{cite journal | vauthors=Jöns T, Drenckhahn D |title=Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells. |journal=Eur. J. Cell Biol. |volume=75 |issue= 3 |pages= 232–6 |year= 1998 |pmid= 9587054 |doi=10.1016/s0171-9335(98)80117-9}}
  • {{cite journal |vauthors=Mobasheri A, Golding S, Pagakis SN, etal |title=Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts. |journal=Cell Biol. Int. |volume=22 |issue= 7–8 |pages= 551–62 |year= 1999 |pmid= 10452823 |doi= 10.1006/cbir.1998.0299 }}
  • {{cite journal | vauthors=Hyde K, Harrison D, Hollingsworth MA, Harris A |title=Chloride-bicarbonate exchangers in the human fetal pancreas. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 2 |pages= 315–21 |year= 1999 |pmid= 10491290 |doi= 10.1006/bbrc.1999.1367 }}
  • {{cite journal |vauthors=Holappa K, Mustonen M, Parvinen M, etal |title=Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis. |journal=Biol. Reprod. |volume=61 |issue= 4 |pages= 981–6 |year= 1999 |pmid= 10491633 |doi=10.1095/biolreprod61.4.981 }}
  • {{cite journal |vauthors=Karet FE, Finberg KE, Nayir A, etal |title=Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34. |journal=Am. J. Hum. Genet. |volume=65 |issue= 6 |pages= 1656–65 |year= 2000 |pmid= 10577919 |doi=10.1086/302679 | pmc=1288376 }}
  • {{cite journal |vauthors=Medina JF, Lecanda J, Acín A, etal |title=Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 1 |pages= 228–35 |year= 2000 |pmid= 10623603 |doi= 10.1006/bbrc.1999.1951 }}
  • {{cite journal | vauthors=Vince JW, Reithmeier RA |title=Identification of the Carbonic Anhydrase II Binding Site in the Cl−/HCO3− Anion Exchanger AE1. |journal=Biochemistry |volume=39 |issue= 18 |pages= 5527–33 |year= 2000 |pmid= 10820026 |doi=10.1021/bi992564p }}
  • {{cite journal | vauthors=Holappa K, Suokas M, Soininen P, Kellokumpu S |title=Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts. |journal=J. Histochem. Cytochem. |volume=49 |issue= 2 |pages= 259–69 |year= 2001 |pmid= 11156694 |doi=10.1177/002215540104900213}}
  • {{cite journal |vauthors=Soleimani M, Greeley T, Petrovic S, etal |title=Pendrin: an apical Cl−/OH−/HCO3− exchanger in the kidney cortex. |journal=Am. J. Physiol. Renal Physiol. |volume=280 |issue= 2 |pages= F356–64 |year= 2001 |pmid= 11208611 |doi=10.1152/ajprenal.2001.280.2.f356}}
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