| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.[1][2]{{PBB_Summary
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}}InteractionsSmall nuclear ribonucleoprotein polypeptide A has been shown to interact with CDC5L.[3] References1. ^{{cite journal |vauthors=Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A, etal | title = Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region | journal = Cytogenet Cell Genet | volume = 54 | issue = 1–2 | pages = 15–9 |date=January 1991 | pmid = 1701111 | pmc = | doi =10.1159/000132946 }}
2. ^{{cite web | title = Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6626| accessdate = }}
3. ^{{cite journal |last=Ajuh |first=P |authorlink= |author2=Kuster B |author3=Panov K |author4=Zomerdijk J C |author5=Mann M |author6=Lamond A I |date=December 2000 |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry |journal=EMBO J. |volume=19 |issue=23 |pages=6569–81 | issn = 0261-4189| pmid = 11101529 |doi = 10.1093/emboj/19.23.6569 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=305846 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Hoffman DW, Query CC, Golden BL, etal |title=RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 6 |pages= 2495–9 |year= 1991 |pmid= 1826055 |doi=10.1073/pnas.88.6.2495 | pmc=51259 |bibcode=1991PNAS...88.2495H }}
- {{cite journal |vauthors=Nelissen RL, Sillekens PT, Beijer RP, etal |title=Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. |journal=Gene |volume=102 |issue= 2 |pages= 189–96 |year= 1991 |pmid= 1831431 |doi=10.1016/0378-1119(91)90077-O }}
- {{cite journal |vauthors=Jessen TH, Oubridge C, Teo CH, etal |title=Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. |journal=EMBO J. |volume=10 |issue= 11 |pages= 3447–56 |year= 1991 |pmid= 1833186 |doi= 10.1002/j.1460-2075.1991.tb04909.x| pmc=453073 }}
- {{cite journal |vauthors=Nagai K, Oubridge C, Jessen TH, etal |title=Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. |journal=Nature |volume=348 |issue= 6301 |pages= 515–20 |year= 1991 |pmid= 2147232 |doi= 10.1038/348515a0 |bibcode=1990Natur.348..515N }}
- {{cite journal |vauthors=Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ |title=cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. |journal=EMBO J. |volume=6 |issue= 12 |pages= 3841–8 |year= 1988 |pmid= 2962859 |doi= 10.1002/j.1460-2075.1987.tb02721.x| pmc=553857 }}
- {{cite journal |vauthors=Oubridge C, Ito N, Evans PR, etal |title=Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. |journal=Nature |volume=372 |issue= 6505 |pages= 432–8 |year= 1994 |pmid= 7984237 |doi= 10.1038/372432a0 |bibcode=1994Natur.372..432O }}
- {{cite journal |vauthors=Howe PW, Nagai K, Neuhaus D, Varani G |title=NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. |journal=EMBO J. |volume=13 |issue= 16 |pages= 3873–81 |year= 1994 |pmid= 8070414 |doi= 10.1002/j.1460-2075.1994.tb06698.x| pmc=395300 }}
- {{cite journal |vauthors=Allain FH, Gubser CC, Howe PW, etal |title=Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation. |journal=Nature |volume=380 |issue= 6575 |pages= 646–50 |year= 1996 |pmid= 8602269 |doi= 10.1038/380646a0 |bibcode=1996Natur.380..646A }}
- {{cite journal |vauthors=Avis JM, Allain FH, Howe PW, etal |title=Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. |journal=J. Mol. Biol. |volume=257 |issue= 2 |pages= 398–411 |year= 1996 |pmid= 8609632 |doi= 10.1006/jmbi.1996.0171 }}
- {{cite journal |vauthors=Lu J, Hall KB |title=Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. |journal=Biochemistry |volume=36 |issue= 34 |pages= 10393–405 |year= 1997 |pmid= 9265619 |doi= 10.1021/bi9709811 }}
- {{cite journal |vauthors=Allain FH, Howe PW, Neuhaus D, Varani G |title=Structural basis of the RNA-binding specificity of human U1A protein. |journal=EMBO J. |volume=16 |issue= 18 |pages= 5764–72 |year= 1997 |pmid= 9312034 |doi= 10.1093/emboj/16.18.5764 | pmc=1170207 }}
- {{cite journal |vauthors=Neubauer G, King A, Rappsilber J, etal |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
- {{cite journal |vauthors=Ferré-D'Amaré AR, Zhou K, Doudna JA |title=Crystal structure of a hepatitis delta virus ribozyme. |journal=Nature |volume=395 |issue= 6702 |pages= 567–74 |year= 1998 |pmid= 9783582 |doi= 10.1038/26912 |bibcode=1998Natur.395..567F }}
- {{cite journal |vauthors=Lutz CS, Cooke C, O'Connor JP, etal |title=The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. |journal=RNA |volume=4 |issue= 12 |pages= 1493–9 |year= 1998 |pmid= 9848648 |doi=10.1017/S1355838298981183 | pmc=1369720 }}
- {{cite journal |vauthors=Hetzer M, Mattaj IW |title=An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins. |journal=J. Cell Biol. |volume=148 |issue= 2 |pages= 293–303 |year= 2000 |pmid= 10648562 |doi=10.1083/jcb.148.2.293 | pmc=2174293 }}
- {{cite journal |vauthors=Klein Gunnewiek JM, Hussein RI, van Aarssen Y, etal |title=Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2209–17 |year= 2000 |pmid= 10688667 |doi=10.1128/MCB.20.6.2209-2217.2000 | pmc=110837 }}
- {{cite journal |vauthors=Varani L, Gunderson SI, Mattaj IW, etal |title=The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. |journal=Nat. Struct. Biol. |volume=7 |issue= 4 |pages= 329–35 |year= 2000 |pmid= 10742179 |doi= 10.1038/74101 }}
- {{cite journal |vauthors=Ajuh P, Kuster B, Panov K, etal |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6569–81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569 | pmc=305846 }}
- {{cite journal |vauthors=Simmons A, Aluvihare V, McMichael A |title=Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. |journal=Immunity |volume=14 |issue= 6 |pages= 763–77 |year= 2001 |pmid= 11420046 |doi=10.1016/S1074-7613(01)00158-3 }}
{{refend}}{{PDB Gallery|geneid=6626}}{{Ribonucleoproteins}}{{gene-19-stub}} |