“SMARCC2”的意思、由来-开放百科全书

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene.^[3]

References

1. ^{{cite journal | vauthors = Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR | title = Diversity and specialization of mammalian SWI/SNF complexes | journal = Genes Dev | volume = 10 | issue = 17 | pages = 2117–30 | date = November 1996 | pmid = 8804307 | pmc = | doi = 10.1101/gad.10.17.2117 }}
2. ^{{cite journal | vauthors = Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U | title = Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome | journal = Genomics | volume = 51 | issue = 1 | pages = 140–3 | date = September 1998 | pmid = 9693044 | pmc = | doi = 10.1006/geno.1998.5343 }}
3. ^¹{{cite web | title = Entrez Gene: SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6601| accessdate = }}
4. ^{{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | language = | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | date = June 2003 | pmid = 12837248 | doi = 10.1016/S0092-8674(03)00436-7 }}
5. ^{{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | language = | journal = EMBO J. | volume = 15 | issue = 19 | pages = 5370–82 | date = October 1996 | pmid = 8895581 | pmc = 452280 }}
6. ^{{cite journal | vauthors = Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM | title = Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex | language = | journal = Hum. Mol. Genet. | volume = 10 | issue = 23 | pages = 2651–60 | date = November 2001 | pmid = 11726552 | doi = 10.1093/hmg/10.23.2651 | url = | authorlink = | laysummary = | oclc = | id = | bibcode = | accessdate = | location = England | laydate = | format = | quote = | publisher = | issn = 0964-6906 | laysource = }}
7. ^{{cite journal | vauthors = Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR | title = Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling | language = | journal = Cell | volume = 95 | issue = 5 | pages = 625–36 | date = November 1998 | pmid = 9845365 | doi = 10.1016/S0092-8674(00)81633-5 }}

Further reading

{{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = EMBO J. | volume = 15 | issue = 19 | pages = 5370–82 | year = 1996 | pmid = 8895581 | pmc = 452280 | doi = }}

{{cite journal | vauthors = Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree GR | title = Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 2 | pages = 492–8 | year = 1998 | pmid = 9435219 | pmc = 18447 | doi = 10.1073/pnas.95.2.492 | bibcode = 1998PNAS...95..492W }}

{{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure | journal = Mol. Cell. Biol. | volume = 18 | issue = 9 | pages = 5355–63 | year = 1998 | pmid = 9710619 | pmc = 109120 | doi = }}

{{cite journal | vauthors = Phelan ML, Sif S, Narlikar GJ, Kingston RE | title = Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits | journal = Mol. Cell | volume = 3 | issue = 2 | pages = 247–53 | year = 1999 | pmid = 10078207 | doi = 10.1016/S1097-2765(00)80315-9 }}

{{cite journal | vauthors = Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R | title = BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer | journal = Cell | volume = 102 | issue = 2 | pages = 257–65 | year = 2000 | pmid = 10943845 | doi = 10.1016/S0092-8674(00)00030-1 }}

{{cite journal | vauthors = Kadam S, McAlpine GS, Phelan ML, Kingston RE, Jones KA, Emerson BM | title = Functional selectivity of recombinant mammalian SWI/SNF subunits | journal = Genes Dev. | volume = 14 | issue = 19 | pages = 2441–51 | year = 2000 | pmid = 11018012 | pmc = 316972 | doi = 10.1101/gad.828000 }}

{{cite journal | vauthors = Xue Y, Canman JC, Lee CS, Nie Z, Yang D, Moreno GT, Young MK, Salmon ED, Wang W | title = The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 24 | pages = 13015–20 | year = 2001 | pmid = 11078522 | pmc = 27170 | doi = 10.1073/pnas.240208597 | bibcode = 2000PNAS...9713015X }}

{{cite journal | vauthors = Sif S, Saurin AJ, Imbalzano AN, Kingston RE | title = Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes | journal = Genes Dev. | volume = 15 | issue = 5 | pages = 603–18 | year = 2001 | pmid = 11238380 | pmc = 312641 | doi = 10.1101/gad.872801 }}

{{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 5498–505 | year = 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}

{{cite journal | vauthors = Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G | title = REST repression of neuronal genes requires components of the hSWI.SNF complex | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 41038–45 | year = 2002 | pmid = 12192000 | doi = 10.1074/jbc.M205691200 }}

{{cite journal | vauthors = Olave I, Wang W, Xue Y, Kuo A, Crabtree GR | title = Identification of a polymorphic, neuron-specific chromatin remodeling complex | journal = Genes Dev. | volume = 16 | issue = 19 | pages = 2509–17 | year = 2002 | pmid = 12368262 | pmc = 187451 | doi = 10.1101/gad.992102 }}

{{cite journal | vauthors = Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W | title = Novel SWI/SNF Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner | journal = Mol. Cell. Biol. | volume = 23 | issue = 8 | pages = 2942–52 | year = 2003 | pmid = 12665591 | pmc = 152562 | doi = 10.1128/MCB.23.8.2942-2952.2003 }}

{{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | year = 2003 | pmid = 12837248 | doi = 10.1016/S0092-8674(03)00436-7 }}

{{cite journal | vauthors = Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK | title = BAF60a Mediates Critical Interactions between Nuclear Receptors and the BRG1 Chromatin-Remodeling Complex for Transactivation | journal = Mol. Cell. Biol. | volume = 23 | issue = 17 | pages = 6210–20 | year = 2003 | pmid = 12917342 | pmc = 180928 | doi = 10.1128/MCB.23.17.6210-6220.2003 }}

{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}

{{cite journal | vauthors = Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH | title = A small modulatory dsRNA specifies the fate of adult neural stem cells | journal = Cell | volume = 116 | issue = 6 | pages = 779–93 | year = 2004 | pmid = 15035981 | doi = 10.1016/S0092-8674(04)00248-X }}

{{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B }}

Function

Interactions

References

Further reading

External links