“S-methyl-5-thioribose kinase”的意思、由来-开放百科全书

词条

S-methyl-5-thioribose kinase

释义

Structural studies
References

{{enzyme
| Name = S-methyl-5-thioribose kinase
| EC_number = 2.7.1.100
| CAS_number = 68247-56-3
| IUBMB_EC_number = 2/7/1/100
| GO_code = 0046522
| image =
| width =
| caption =
}}

In enzymology, a S-methyl-5-thioribose kinase ({{EC number|2.7.1.100}}) is an enzyme that catalyzes the chemical reaction

ATP + S-methyl-5-thio-D-ribose ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are ATP and S-methyl-5-thio-D-ribose, whereas its two products are ADP and S-methyl-5-thio-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:S-methylmethyl-5-thio-D-ribose 1-phosphotransferase. Other names in common use include 5-methylthioribose kinase (phosphorylating), methylthioribose kinase, 5-methylthioribose kinase, and ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase. This enzyme participates in methionine metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2OLC}}, {{PDB link|2PU8}}, {{PDB link|2PUI}}, {{PDB link|2PUL}}, {{PDB link|2PUN}}, and {{PDB link|2PUP}}.

References

{{cite journal |vauthors=Ferro AJ, Barrett A, Shapiro SK | date = 1978 | title = 5-Methylthioribose kinase. A new enzyme involved in the formation of methionine from 5-methylthioribose | journal = J. Biol. Chem. | volume = 253 | pages = 6021–5 | pmid = 210167 | issue = 17 }}
{{cite journal | author = Guranowski A | date = 1983 | title = Plant 5-methylthioribose kinase | journal = Plant Physiol. | volume = 71 | pages = 932–935 | pmid=16662931 | doi=10.1104/pp.71.4.932 | pmc=1066146}}

2 : EC 2.7.1|Enzymes of known structure

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