Mercurialis may refer to:

• Mercurialis (plant) a genus of plants in the Euphorbiaceae family
• Hieronymus Mercurialis (1530-1606), Latin name of Girolamo Mercuriale, an Italian philologist and physician
• Mercurialis of Forlì (?-ca. 406), bishop of Forlì

• Trisomy 8
• Trisomy Disorders
• Trisomy X
• Trisomy-x
• Trison Detsen
• Trisong Detsen
• Trisong Deutsen
• Trisong Deutson
• Trisopterus minutus
• Triss
• Trissino, Giangiorgio
• Tris Speaker
• Trissur Pooram
• Tristam (disambiguation)
• Trista Meioh
• Tristan
• Tristan A. Farnon
• Tristan and Iseult
• Tristan and Iseult (disambiguation)
• Tristan Bernard
• Tristan chord
• Tristan Corbiere
• Tristan Corbière
• Tristan Da Cunha
• Tristan da cunha