| 词条 | SNX6 |
| 释义 |
| Name = sorting nexin 6 | caption = | image = | width = | HGNCid = 14970 | Symbol = SNX6 | AltSymbols = | EntrezGene = 58533 | OMIM = 606098 | RefSeq = NM_021249 | UniProt = Q9UNH7 | PDB = | ECnumber = | Chromosome = 14 | Arm = q | Band = 13 | LocusSupplementaryData = }}Sorting Nexin 6 also known as SNX6 is a well-conserved membrane-associated protein belonging to the sorting nexin family that is a component of the retromer complex.[1] The protein contains a coiled-coil domain at its C terminus and a PX domain at its N terminus. Binding to PIM1 causes translocation to the nucleus.[2] SNX6 has been shown to associate with TRAF4.[3] References1. ^{{cite journal | vauthors = Wassmer T, Attar N, Bujny MV, Oakley J, Traer CJ, Cullen PJ | title = A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer | journal = J. Cell Sci. | volume = 120 | issue = Pt 1 | pages = 45–54 |date=January 2007 | pmid = 17148574 | doi = 10.1242/jcs.03302 | url = | issn = }} {{Sorting nexins}}{{gene-14-stub}}2. ^{{cite journal | vauthors = Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ | title = Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19332–9 |date=June 2001 | pmid = 11279102 | doi = 10.1074/jbc.M100606200 | url = | issn = }} 3. ^{{cite journal | vauthors = Ishibashi Y, Maita H, Yano M, Koike N, Tamai K, Ariga H, Iguchi-Ariga SM | title = Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus | journal = FEBS Lett. | volume = 506 | issue = 1 | pages = 33–8 |date=September 2001 | pmid = 11591366 | doi = 10.1016/S0014-5793(01)02881-2 | url = | issn = }} |
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