请输入您要查询的百科知识：

　

词条 SORBS1
释义

  1. Structure

  2. Function

  3. Clinical Significance

  4. Interactions

  5. References

  6. Further reading

{{Infobox_gene}}

CAP/Ponsin protein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1 gene.[1][2][3] CAP/Ponsin is part of a small family of adaptor proteins that regulate cell adhesion, growth factor signaling and cytoskeletal formation. CAP/Ponsin is mainly expressed in heart, skeletal muscle, liver, adipose tissue, and macrophages; in striated muscle tissue, CAP/Ponsin is localized to costamere structures.

Structure

CAP/Ponsin may exist as thirteen alternatively-spliced isoforms, ranging from 81 kDa to 142 kDa.[4] CAP/Ponsin is part of an adaptor protein family, of which ArgBP2 and vinexin are also a part.[5] These proteins contain a conserved sorbin homology (SOHO) domain and three SH3 domains, and CAP/Ponsin is expressed in heart, skeletal muscle, liver, adipose tissue, and macrophages.[4][6][7]

Function

In muscle, CAP/Ponsin plays a role in the formation of mature costameres from focal adhesion-like contacts during assembly of the contractile apparatus, as overexpression of CAP/Ponsin disrupted normal cell-matrix contact morphology.[8] In a mouse model of viral myocarditis due to Coxsackievirus infection, CAP/Ponsin stabilized antiviral type I interferon production and was protective against apoptosis and cytotoxicity.[9] CAP/Ponsin has also been shown to be a major regulator of insulin-stimulated signaling and regulation of glucose uptake, by potentiating insulin-induced phosphorylation and recruitment of CBL to a lipid raft signaling complex involving flotillin.[10] A role for CAP/Ponsin in macrophage function was illuminated by the finding that mice harboring SORBS1-deficient macrophages in bone marrow was protective against high-fat diet-induced insulin resistance and showed reduced inflammation.[7] In non-muscle cells, CAP/Ponsin inhibits cell spreading and focal adhesion turnover, as its siRNA-mediated knockdown resulted in enhanced PAK/MEK/ERK activation and cell migration.[11]

Clinical Significance

CAP/Ponsin was demonstrated to be down-regulated in end-stage heart failure patients; an effect that was restored upon mechanical unloading.[8] A single nucleotide polymorphism in SORBS1 was found to be associated with type 2 diabetes and obesity.[12]

Interactions

SORBS1 has been shown to interact with:

{{div col|colwidth=20em}}
  • CBL,[16][13]
  • FLOT1,[2][14][15]
  • INPPL1,[13]
  • INSM1,[16]
  • MLLT4,[1]
  • PXN,[8] and
  • Vinculin.[1]
{{Div col end}}{{Clear}}

References

1. ^1 2 {{cite journal | vauthors = Mandai K, Nakanishi H, Satoh A, Takahashi K, Satoh K, Nishioka H, Mizoguchi A, Takai Y | title = Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions | journal = The Journal of Cell Biology | volume = 144 | issue = 5 | pages = 1001–17 | date = Mar 1999 | pmid = 10085297 | pmc = 2148189 | doi = 10.1083/jcb.144.5.1001 }}
2. ^1 {{cite journal | vauthors = Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR | title = CAP defines a second signalling pathway required for insulin-stimulated glucose transport | journal = Nature | volume = 407 | issue = 6801 | pages = 202–7 | date = Sep 2000 | pmid = 11001060 | pmc = | doi = 10.1038/35025089 | url = https://deepblue.lib.umich.edu/bitstream/2027.42/62940/1/407202a0.pdf }}
3. ^{{Cite web| title = Entrez Gene: SORBS1 sorbin and SH3 domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10580| accessdate = }}
4. ^1 {{cite journal | vauthors = Lin WH, Huang CJ, Liu MW, Chang HM, Chen YJ, Tai TY, Chuang LM | title = Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B | journal = Genomics | volume = 74 | issue = 1 | pages = 12–20 | date = May 2001 | pmid = 11374898 | doi = 10.1006/geno.2001.6541 }}
5. ^{{cite journal | pmid = 11937713 | doi=10.1247/csf.27.1 | volume=27 | title=Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction. | date=Feb 2002 | journal=Cell Struct Funct | pages=1–7 | vauthors=Kioka N, Ueda K, Amachi T}}
6. ^{{cite journal | vauthors = Ribon V, Printen JA, Hoffman NG, Kay BK, Saltiel AR | title = A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes | journal = Molecular and Cellular Biology | volume = 18 | issue = 2 | pages = 872–9 | date = Feb 1998 | pmid = 9447983 | doi=10.1128/mcb.18.2.872 | pmc=108798}}
7. ^1 {{cite journal | vauthors = Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM | title = Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance | journal = Nature Medicine | volume = 13 | issue = 4 | pages = 455–62 | date = Apr 2007 | pmid = 17351624 | doi = 10.1038/nm1550 }}
8. ^1 2 {{cite journal | vauthors = Gehmlich K, Pinotsis N, Hayess K, van der Ven PF, Milting H, El Banayosy A, Körfer R, Wilmanns M, Ehler E, Fürst DO | title = Paxillin and ponsin interact in nascent costameres of muscle cells | journal = Journal of Molecular Biology | volume = 369 | issue = 3 | pages = 665–82 | date = Jun 2007 | pmid = 17462669 | doi = 10.1016/j.jmb.2007.03.050 }}
9. ^{{cite journal | vauthors = Valaperti A, Nishii M, Liu Y, Yang H, Naito K, Liu PP, Eriksson U | title = The adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicity | journal = Basic Research in Cardiology | volume = 109 | issue = 3 | pages = 411 | date = May 2014 | pmid = 24763933 | doi = 10.1007/s00395-014-0411-3 }}
10. ^{{cite journal | vauthors = Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR | title = CAP defines a second signalling pathway required for insulin-stimulated glucose transport | journal = Nature | volume = 407 | issue = 6801 | pages = 202–7 | date = Sep 2000 | pmid = 11001060 | doi = 10.1038/35025089 }}
11. ^{{cite journal | vauthors = Zhang M, Liu J, Cheng A, Deyoung SM, Chen X, Dold LH, Saltiel AR | title = CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility | journal = The EMBO Journal | volume = 25 | issue = 22 | pages = 5284–93 | date = Nov 2006 | pmid = 17082770 | doi = 10.1038/sj.emboj.7601406 | pmc=1636617}}
12. ^{{cite journal | vauthors = Lin WH, Chiu KC, Chang HM, Lee KC, Tai TY, Chuang LM | title = Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes | journal = Human Molecular Genetics | volume = 10 | issue = 17 | pages = 1753–60 | date = Aug 2001 | pmid = 11532984 | doi=10.1093/hmg/10.17.1753}}
13. ^1 {{cite journal | vauthors = Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I | title = The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2 | journal = Biochemical and Biophysical Research Communications | volume = 300 | issue = 2 | pages = 494–500 | date = Jan 2003 | pmid = 12504111 | doi = 10.1016/s0006-291x(02)02894-2}}
14. ^1 {{cite journal | vauthors = Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I | title = Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites | journal = Journal of Cell Science | volume = 117 | issue = Pt 12 | pages = 2557–68 | date = May 2004 | pmid = 15128873 | doi = 10.1242/jcs.01148 }}
15. ^{{cite journal | vauthors = Kimura A, Baumann CA, Chiang SH, Saltiel AR | title = The sorbin homology domain: a motif for the targeting of proteins to lipid rafts | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 16 | pages = 9098–103 | date = Jul 2001 | pmid = 11481476 | pmc = 55379 | doi = 10.1073/pnas.151252898 }}
16. ^{{cite journal | vauthors = Xie J, Cai T, Zhang H, Lan MS, Notkins AL | title = The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein | journal = Genomics | volume = 80 | issue = 1 | pages = 54–61 | date = Jul 2002 | pmid = 12079283 | pmc = 1237014 | doi = 10.1006/geno.2002.6800}}

Further reading

{{Refbegin|33em}}
  • {{cite journal | vauthors = Kioka N | title = [A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2] | journal = Seikagaku. The Journal of Japanese Biochemical Society | volume = 74 | issue = 11 | pages = 1356–60 | date = Nov 2002 | pmid = 12510380 | doi = }}
  • {{cite journal | vauthors = Ribon V, Herrera R, Kay BK, Saltiel AR | title = A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions | journal = The Journal of Biological Chemistry | volume = 273 | issue = 7 | pages = 4073–80 | date = Feb 1998 | pmid = 9461600 | doi = 10.1074/jbc.273.7.4073 }}
  • {{cite journal | vauthors = Asakura T, Nakanishi H, Sakisaka T, Takahashi K, Mandai K, Nishimura M, Sasaki T, Takai Y | title = Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells | journal = Genes to Cells | volume = 4 | issue = 10 | pages = 573–81 | date = Oct 1999 | pmid = 10583506 | doi = 10.1046/j.1365-2443.1999.00283.x }}
  • {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 1 | pages = 65–73 | date = Feb 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 }}
  • {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
  • {{cite journal | vauthors = Lebre AS, Jamot L, Takahashi J, Spassky N, Leprince C, Ravisé N, Zander C, Fujigasaki H, Kussel-Andermann P, Duyckaerts C, Camonis JH, Brice A | title = Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions | journal = Human Molecular Genetics | volume = 10 | issue = 11 | pages = 1201–13 | date = May 2001 | pmid = 11371513 | doi = 10.1093/hmg/10.11.1201 }}
  • {{cite journal | vauthors = Lin WH, Huang CJ, Liu MW, Chang HM, Chen YJ, Tai TY, Chuang LM | title = Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B | journal = Genomics | volume = 74 | issue = 1 | pages = 12–20 | date = May 2001 | pmid = 11374898 | doi = 10.1006/geno.2001.6541 }}
  • {{cite journal | vauthors = Kimura A, Baumann CA, Chiang SH, Saltiel AR | title = The sorbin homology domain: a motif for the targeting of proteins to lipid rafts | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 16 | pages = 9098–103 | date = Jul 2001 | pmid = 11481476 | pmc = 55379 | doi = 10.1073/pnas.151252898 }}
  • {{cite journal | vauthors = Lin WH, Chiu KC, Chang HM, Lee KC, Tai TY, Chuang LM | title = Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes | journal = Human Molecular Genetics | volume = 10 | issue = 17 | pages = 1753–60 | date = Aug 2001 | pmid = 11532984 | doi = 10.1093/hmg/10.17.1753 }}
  • {{cite journal | vauthors = Cowan CA, Henkemeyer M | title = The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals | journal = Nature | volume = 413 | issue = 6852 | pages = 174–9 | date = Sep 2001 | pmid = 11557983 | doi = 10.1038/35093123 }}
  • {{cite journal | vauthors = Liu J, Kimura A, Baumann CA, Saltiel AR | title = APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes | journal = Molecular and Cellular Biology | volume = 22 | issue = 11 | pages = 3599–609 | date = Jun 2002 | pmid = 11997497 | pmc = 133825 | doi = 10.1128/MCB.22.11.3599-3609.2002 }}
  • {{cite journal | vauthors = Xie J, Cai T, Zhang H, Lan MS, Notkins AL | title = The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein | journal = Genomics | volume = 80 | issue = 1 | pages = 54–61 | date = Jul 2002 | pmid = 12079283 | pmc = 1237014 | doi = 10.1006/geno.2002.6800 }}
  • {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = Nov 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
  • {{cite journal | vauthors = Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I | title = The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2 | journal = Biochemical and Biophysical Research Communications | volume = 300 | issue = 2 | pages = 494–500 | date = Jan 2003 | pmid = 12504111 | doi = 10.1016/S0006-291X(02)02894-2 }}
  • {{cite journal | vauthors = Yang WS, Lee WJ, Huang KC, Lee KC, Chao CL, Chen CL, Tai TY, Chuang LM | title = mRNA levels of the insulin-signaling molecule SORBS1 in the adipose depots of nondiabetic women | journal = Obesity Research | volume = 11 | issue = 4 | pages = 586–90 | date = Apr 2003 | pmid = 12690089 | doi = 10.1038/oby.2003.82 }}
{{Refend}}{{PDB Gallery|geneid=10580}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/22 10:30:56