Southern Avenue may refer to:

In India:

• Southern Avenue (Kolkata)

In the United States:

• Southern Avenue (Washington, D.C.), forming part of the border with Maryland
• Southern Avenue (Washington Metro), a metro station in Prince George's County, Maryland
• Southern Avenue (band), an American five-piece blues and soul blues band from Memphis, Tennessee

• Witch–which merger
• Witcolate A
• Witcomb Court
• WITD-CD
• Witeck-Combs Communications, Inc.
• Witeck Communications, Inc.
• Witek
• Witekind
• WiTel Corp.
• Witenwasserenstock (3,025 m)
• Witer
• Wit FM
• Witfontein
• WITH
• With 100 Kazoos
• With a Bang
• With a Bang (Case Closed)
• Withaferin
• Withaferin A
• Withaferin-A
• With a Girl like You
• With a Gun
• With (album)
• With a Little Bit of Luck
• With a Little Help