“SOX6”的意思、由来-开放百科全书

Function

The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM]^[2]

Interactions

It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near SOX6 transcriptional start site.^[5]

Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells.^[6] In addition, SOX6 may have a role in tumor growth of Ewing sarcoma. ^[7]

See also

References

1. ^{{cite journal | vauthors = Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH | title = Cloning, characterization and chromosome mapping of the human SOX6 gene | journal = Gene | volume = 265 | issue = 1-2 | pages = 157–64 | date = Mar 2001 | pmid = 11255018 | pmc = | doi = 10.1016/S0378-1119(01)00346-8 }}
2. ^¹{{cite web | title = Entrez Gene: SOX6 SRY (sex determining region Y)-box 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55553| accessdate = }}
3. ^{{cite journal | vauthors = Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C | title = SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter | journal = Nucleic Acids Research | volume = 29 | issue = 16 | pages = 3347–55 | date = Aug 2001 | pmid = 11504872 | pmc = 55854 | doi = 10.1093/nar/29.16.3347 }}
4. ^{{cite journal | vauthors = Yamashita A, Ito M, Takamatsu N, Shiba T | title = Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis | journal = FEBS Letters | volume = 481 | issue = 2 | pages = 147–51 | date = Sep 2000 | pmid = 10996314 | doi = 10.1016/S0014-5793(00)01987-6 }}
5. ^{{cite journal | vauthors = Cantu' C, Grande V, Alborelli I, Cassinelli L, Cantu' I, Colzani MT, Ierardi R, Ronzoni L, Cappellini MD, Ferrari G, Ottolenghi S, Ronchi A | title = A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells | journal = Nucleic Acids Research | volume = 39 | issue = 2 | pages = 486–501 | date = Jan 2011 | pmid = 20852263 | pmc = 3025548 | doi = 10.1093/nar/gkq819 }}
6. ^{{cite journal | vauthors = Cantù C, Ierardi R, Alborelli I, Fugazza C, Cassinelli L, Piconese S, Bosè F, Ottolenghi S, Ferrari G, Ronchi A | title = Sox6 enhances erythroid differentiation in human erythroid progenitors | journal = Blood | volume = 117 | issue = 13 | pages = 3669–79 | date = Mar 2011 | doi = 10.1182/blood-2010-04-282350 | pmid = 21263153 }}
7. ^{{Cite journal|last=Marchetto|first=A|display-authors=et al. |date=2019-03-14|title=Oncogenic hijacking of a developmental transcription factor evokes therapeutic vulnerability for ROS-induction in Ewing sarcoma |journal=bioRxiv|language=en|volume=|pages=578666|doi=10.1101/578666|via=}}

Further reading

{{cite journal | vauthors = Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A | title = A conserved family of genes related to the testis determining gene, SRY | journal = Nucleic Acids Research | volume = 20 | issue = 11 | pages = 2887 | date = Jun 1992 | pmid = 1614875 | pmc = 336939 | doi = 10.1093/nar/20.11.2887 }}

{{cite journal | vauthors = Lefebvre V, Li P, de Crombrugghe B | title = A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene | journal = The EMBO Journal | volume = 17 | issue = 19 | pages = 5718–33 | date = Oct 1998 | pmid = 9755172 | pmc = 1170900 | doi = 10.1093/emboj/17.19.5718 }}

{{cite journal | vauthors = Hagiwara N, Klewer SE, Samson RA, Erickson DT, Lyon MF, Brilliant MH | title = Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 8 | pages = 4180–5 | date = Apr 2000 | pmid = 10760285 | pmc = 18189 | doi = 10.1073/pnas.97.8.4180 }}

{{cite journal | vauthors = Yamashita A, Ito M, Takamatsu N, Shiba T | title = Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis | journal = FEBS Letters | volume = 481 | issue = 2 | pages = 147–51 | date = Sep 2000 | pmid = 10996314 | doi = 10.1016/S0014-5793(00)01987-6 }}

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}

{{cite journal | vauthors = Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C | title = SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter | journal = Nucleic Acids Research | volume = 29 | issue = 16 | pages = 3347–55 | date = Aug 2001 | pmid = 11504872 | pmc = 55854 | doi = 10.1093/nar/29.16.3347 }}

{{cite journal | vauthors = Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH | title = Sox6 regulation of cardiac myocyte development | journal = Nucleic Acids Research | volume = 31 | issue = 20 | pages = 5941–8 | date = Oct 2003 | pmid = 14530442 | pmc = 219484 | doi = 10.1093/nar/gkg807 }}

{{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}

{{cite journal | vauthors = Ueda R, Yoshida K, Kawakami Y, Kawase T, Toda M | title = Expression of a transcriptional factor, SOX6, in human gliomas | journal = Brain Tumor Pathology | volume = 21 | issue = 1 | pages = 35–8 | year = 2005 | pmid = 15696967 | doi = 10.1007/BF02482175 }}

{{cite journal | vauthors = Ueda R, Yoshida K, Kawakami Y, Kawase T, Toda M | title = Immunohistochemical analysis of SOX6 expression in human brain tumors | journal = Brain Tumor Pathology | volume = 21 | issue = 3 | pages = 117–20 | year = 2005 | pmid = 15696972 | doi = 10.1007/BF02482186 }}

{{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}

{{cite journal | vauthors = Fernández-Lloris R, Osses N, Jaffray E, Shen LN, Vaughan OA, Girwood D, Bartrons R, Rosa JL, Hay RT, Ventura F | title = Repression of SOX6 transcriptional activity by SUMO modification | journal = FEBS Letters | volume = 580 | issue = 5 | pages = 1215–21 | date = Feb 2006 | pmid = 16442531 | doi = 10.1016/j.febslet.2006.01.031 }}

{{cite journal | vauthors = Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI | title = Identification and characterization of the human SOX6 promoter | journal = Biochemical and Biophysical Research Communications | volume = 357 | issue = 2 | pages = 383–90 | date = Jun 2007 | pmid = 17433257 | doi = 10.1016/j.bbrc.2007.03.133 }}

Function

Interactions

See also

References

Further reading

External links