| 释义 |
- See also
- References
- Further reading
{{Infobox_gene}}SPARC-like protein 1 (SPARCL1 or SC1), also known as hevin (short for high endothelial venule protein), is a secreted protein with high structural similarity to SPARC.[1][2] It interacts with the extracellular matrix to create intermediate states of cell adhesion.[3] Due to its dynamic extracellular roles, being implicated in cancer metastasis and inflammation, it is considered a matricellular protein.[4][5] In humans hevin is encoded by the SPARCL1 gene.[6][7] See also References 1. ^{{cite journal | vauthors = Girard JP, Springer TA | title = Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC | journal = Immunity | volume = 2 | issue = 1 | pages = 113–23 | date = Jan 1995 | pmid = 7600298 | pmc = | doi = 10.1016/1074-7613(95)90083-7 }}
2. ^{{cite journal | vauthors = Hambrock HO, Nitsche DP, Hansen U, Bruckner P, Paulsson M, Maurer P, Hartmann U | title = SC1/hevin. An extracellular calcium-modulated protein that binds collagen I | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11351–8 | date = Mar 2003 | pmid = 12538579 | doi = 10.1074/jbc.M212291200 }}
3. ^{{cite journal | vauthors = Sullivan MM, Barker TH, Funk SE, Karchin A, Seo NS, Höök M, Sanders J, Starcher B, Wight TN, Puolakkainen P, Sage EH | title = Matricellular hevin regulates decorin production and collagen assembly | journal = The Journal of Biological Chemistry | volume = 281 | issue = 37 | pages = 27621–32 | date = Sep 2006 | pmid = 16844696 | pmc = | doi = 10.1074/jbc.M510507200 }}
4. ^{{cite journal | vauthors = Morris AH, Kyriakides TR | title = Matricellular proteins and biomaterials | journal = Matrix Biology | volume = 37 | pages = 183–91 | date = Jul 2014 | pmid = 24657843 | doi = 10.1016/j.matbio.2014.03.002 | pmc=4167162}}
5. ^{{cite journal | vauthors = Sullivan MM, Sage EH | title = Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family | journal = The International Journal of Biochemistry & Cell Biology | volume = 36 | issue = 6 | pages = 991–6 | date = Jun 2004 | pmid = 15094114 | doi = 10.1016/j.biocel.2004.01.017 }}
6. ^{{cite journal | vauthors = Schraml P, Shipman R, Stulz P, Ludwig CU | title = cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST) | journal = Trends in Genetics | volume = 9 | issue = 3 | pages = 70–1 | date = Mar 1993 | pmid = 8488563 | pmc = | doi = 10.1016/0168-9525(93)90216-5 }}
7. ^{{cite web | title = Entrez Gene: SPARCL1 SPARC-like 1 (mast9, hevin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8404| accessdate = }}
{{clear}} Further reading {{refbegin | 2}}- {{cite journal | vauthors = Girard JP, Springer TA | title = Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules | journal = The Journal of Biological Chemistry | volume = 271 | issue = 8 | pages = 4511–7 | date = Feb 1996 | pmid = 8626806 | doi = 10.1074/jbc.271.8.4511 }}
- {{cite journal | vauthors = Claeskens A, Ongenae N, Neefs JM, Cheyns P, Kaijen P, Cools M, Kutoh E | title = Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation | journal = British Journal of Cancer | volume = 82 | issue = 6 | pages = 1123–30 | date = Mar 2000 | pmid = 10735494 | pmc = 2363342 | doi = 10.1054/bjoc.1999.1051 }}
- {{cite journal | vauthors = Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA | title = Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 724–31 | date = Jun 2004 | pmid = 15146195 | doi = 10.1038/nbt969 }}
- {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
- {{cite journal | vauthors = Li Y, Aroca-Aguilar JD, Ghosh S, Sánchez-Sánchez F, Escribano J, Coca-Prados M | title = Interaction of myocilin with the C-terminal region of hevin | journal = Biochemical and Biophysical Research Communications | volume = 339 | issue = 3 | pages = 797–804 | date = Jan 2006 | pmid = 16316624 | doi = 10.1016/j.bbrc.2005.11.082 }}
- {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry | journal = Journal of Proteome Research | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
- {{cite journal | vauthors = Scalabrini D, Fenoglio C, Scarpini E, De Riz M, Comi C, Venturelli E, Cortini F, Piola M, Villa C, Naldi P, Monaco F, Bresolin N, Galimberti D | title = Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis | journal = Neuroscience Letters | volume = 425 | issue = 3 | pages = 173–6 | date = Oct 2007 | pmid = 17825989 | doi = 10.1016/j.neulet.2007.08.020 }}
{{refend}} 5 : Extracellular matrix proteins|Matricellular proteins|Cell adhesion proteins|Genes on human chromosome 4|EF-hand-containing proteins |