| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM][3]
}}InteractionsSPDEF has been shown to interact with NKX3-1.[4] The Protein Kinase CK2 has been shown to control the stability of PDEF.[5] Needed for the differentiation of both pulmonary and intestinal goblet cells References1. ^{{cite journal |author1=Oettgen P |author2=Finger E |author3=Sun Z |author4=Akbarali Y |author5=Thamrongsak U |author6=Boltax J |author7=Grall F |author8=Dube A |author9=Weiss A |author10=Brown L |author11=Quinn G |author12=Kas K |author13=Endress G |author14=Kunsch C |author15=Libermann TA | title = PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression | journal = J Biol Chem | volume = 275 | issue = 2 | pages = 1216–25 |date=February 2000 | pmid = 10625666 | pmc = | doi =10.1074/jbc.275.2.1216 }}
2. ^{{cite journal |author1=Johannessen JV |author2=Finseth I | title = Electron micrographs in five minutes | journal = Ultrastruct Pathol | volume = 4 | issue = 1 | pages = 97–100 |date=July 1983 | pmid = 6857767 | pmc = | doi =10.3109/01913128309140576 }}
3. ^1 {{cite web | title = Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25803| accessdate = }}
4. ^{{cite journal |last=Chen |first=Hui |authorlink= |author2=Nandi Asit K |author3=Li Xiang |author4=Bieberich Charles J |date=January 2002 |title=NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter |journal=Cancer Res. |volume=62 |issue=2 |pages=338–40 |publisher= |location = United States| issn = 0008-5472| pmid = 11809674 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
5. ^{{cite journal |last=Chisholm |first=Christine |authorlink= |author2=Padmanabhan Achuth |author3=Guan Bin |author4=Li Xiang |author5=Kalra Simran |author6=Bieberich Charles J |date= 2010 |title=Protein Kinase CK2 regulates the stability of prostate derived Ets factor |journal= The Open Cancer Journal |volume=3 | pages=109–115 |publisher= Bentham Science|doi=10.2174/1874079001003010109}}http://www.benthamscience.com/open/tocj/articles/V003/SI0022TOCJ/109TOCJ.pdf
Further reading{{refbegin | 2}}- {{cite journal | author=Lance V |title=Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions. |journal=Comparative Biochemistry and Physiology A |volume=53 |issue= 3 |pages= 285–9 |year= 1976 |pmid= 2437 |doi=10.1016/S0300-9629(76)80037-0 }}
- {{cite journal |author1=Yamada N |author2=Tamai Y |author3=Miyamoto H |author4=Nozaki M |title=Cloning and expression of the mouse Pse gene encoding a novel Ets family member. |journal=Gene |volume=241 |issue= 2 |pages= 267–74 |year= 2000 |pmid= 10675039 |doi=10.1016/S0378-1119(99)00484-9 }}
- {{cite journal |author1=Chen H |author2=Nandi AK |author3=Li X |author4=Bieberich CJ |title=NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. |journal=Cancer Res. |volume=62 |issue= 2 |pages= 338–40 |year= 2002 |pmid= 11809674 |doi= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Thompson HG, Harris JW, Wold BJ, etal |title=p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells. |journal=Oncogene |volume=22 |issue= 15 |pages= 2322–33 |year= 2003 |pmid= 12700667 |doi= 10.1038/sj.onc.1206325 }}
- {{cite journal |vauthors=Feldman RJ, Sementchenko VI, Gayed M, etal |title=Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression. |journal=Cancer Res. |volume=63 |issue= 15 |pages= 4626–31 |year= 2003 |pmid= 12907642 |doi= }}
- {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
- {{cite journal |vauthors=Ghadersohi A, Odunsi K, Lele S, etal |title=Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules. |journal=Oncol. Rep. |volume=11 |issue= 2 |pages= 453–8 |year= 2004 |pmid= 14719083 |doi= 10.3892/or.11.2.453}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |author1=Chen H |author2=Bieberich CJ |title=Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF. |journal=J. Cell. Biochem. |volume=94 |issue= 1 |pages= 168–77 |year= 2005 |pmid= 15523673 |doi= 10.1002/jcb.20297 }}
- {{cite journal |vauthors=Wang Y, Feng L, Said M, etal |title=Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site. |journal=Biochemistry |volume=44 |issue= 19 |pages= 7095–106 |year= 2005 |pmid= 15882048 |doi= 10.1021/bi047352t }}
- {{cite journal |vauthors=Fowler M, Borazanci E, McGhee L, etal |title=RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region. |journal=J. Cell. Biochem. |volume=97 |issue= 1 |pages= 1–17 |year= 2006 |pmid= 16237704 |doi= 10.1002/jcb.20664 }}
- {{cite journal |vauthors=Gunawardane RN, Sgroi DC, Wrobel CN, etal |title=Novel role for PDEF in epithelial cell migration and invasion. |journal=Cancer Res. |volume=65 |issue= 24 |pages= 11572–80 |year= 2006 |pmid= 16357167 | pmc=2919290 |doi= 10.1158/0008-5472.CAN-05-1196 }}
- {{cite journal |vauthors=Rodabaugh KJ, Mhawech-Fauceglia P, Groth J, etal |title=Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors. |journal=Int. J. Gynecol. Pathol. |volume=26 |issue= 1 |pages= 10–5 |year= 2007 |pmid= 17197890 |doi= 10.1097/01.pgp.0000225386.41244.bd }}
- {{cite journal |vauthors=Park KS, Korfhagen TR, Bruno MD, etal |title=SPDEF regulates goblet cell hyperplasia in the airway epithelium. |journal=J. Clin. Invest. |volume=117 |issue= 4 |pages= 978–88 |year= 2007 |pmid= 17347682 |doi= 10.1172/JCI29176 | pmc=1810569 }}
{{refend}}{{PDB Gallery|geneid=25803}}{{gene-6-stub}} |